Some new amides of 5-Sulphosalicylic acid were synthesized by the reaction of suitable amines with 5-sulphosalicylic acid in 2:1 ratio. The compounds are novel and first time screened for their complete biological evaluation along with general characterization with the help of elemental and IR spectral analysis. These compounds showed higher to moderate biological activity against different pathogenic microbial strains.

The aim of this study was to investigate the protective effect of plant compound idopyranose is evaluated against streptozotocin-induced diabetics Wistar rats. The animals were divided into four groups consisting of 6 rats each. Group I contained the normal control were treated with olive oil, group II was served as a negative control (diabetic control), group III comprising normal rats were administered with idopyranose alone for 21 days and group IV diabetic rats were administered with idopyranose (50 mg /kg body wt/ day orally) respectively. Diabetic rats were given idopyranose isolated from the plant, Vitex negundo showed significant reduction in blood glucose, alanine aminotransaminase and aspirate aminotransaminase activities. Serum urea, creatinine and cholesterol were also significantly reduced when compared to diabetic control. Apart from these parameters, idopyranose showed improvement in parameters like body weight, lipid profile such as triglyceride, high density lipoprotein (HDL) and low density lipoprotein (LDL). In diabetic rats changes like coarsening of acinar cells of endoplasmic reticulation, destruction of beta cells and alternation in their secretary function were observed in the histomorphology of the pancreas. The changes like dilation of vein, loss of unusual concentric arrangement of hepatocytes and liver fibrosis were observed in the liver. Thickening of tubules and expansion of glomerulus were observed in kidneys. All these altered parameters were reversed close to normal condition by the treatment of idopyranose. According to biochemical and histological results obtained, it can be concluded that the idopyranose helps in regeneration of damaged pancreas and protects pancreatic ß cells and hyperglycemic nature against streptozotocin-induced diabetes.

A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for estimation of Flupenthixol Hydrochloride in pharmaceutical dosage forms. The method was carried out on a Eurospher C18 (250 cm×4 mm) column with precolumn and a mobile phase consisting of Acetonitrile:Water (pH 3.0) (50:50 v/v) at a flow rate of 1 ml/min. Detection was carried out at 229nm. Acetonitrile was used as an internal standard. The retention time of Flupenthixol HCl was found out to be 3.98. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantization and solution stability. The proposed method can be used for the estimation of these drugs in combined dosage forms.

Siddha system of medicine (SSM) is one of the oldest traditional systems of medicine, which has been originated from India and is practiced mostly in the southern part of this country for treating various diseases including even chronic conditions. However, it is relatively veiled to the scientific community as compared to other traditional systems such as Ayurveda (a popular Indian medicine), TCM (traditional Chinese medicine) and Kampo (traditional Japanese medicine). Respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) are a serious health problem, which are increasing rapidly worldwide. The current therapy has its own shortcomings and notable adverse effects. There is an intense need to search some safer alternative therapy for treating these epidemic diseases. The objectives of this article is, first, to increase the awareness about SSM to the scientific community, thus inviting more scientific studies on this system, and secondly, to list certain medicinal plants of this system which are commonly used for treating respiratory diseases. To explore the possibility for obtaining potential drugs from these plants, certain future perspectives have also been discussed.

Post-genomic biology seeks identification and quantification of multiple proteins from complex mixtures and the research is still on. Despite recent progress in high-throughput proteomics, proteomic analysis of post-translationally modified [PTM] proteins remains particularly challenging. Several strategies for isolating phosphoproteins are explored herein. Quantification of phosphoproteins seems to be a novel solution to identify the underlying disease mechanisms, mostly cancer.

A current research is showing correlation between serum billirubin and coronary arterial disease. CAD is most common in man than in female. Because in this there is also one phenomena work behind it was level of serum billirubin which is maintain in female by estrogen where as in male there is no maintenances of S. billirubin this is lower in mail compare to female. Another risk factor also work in male rather than female is like smoking, diabetic or level of blood sugar and also B.M.I..

In this study Diclofenac sodium-containing ethyl cellulose micro particles were prepared by the Emulsion-solvent evaporation method with a view for use in the application of magnetic carrier technology. The properties of these magnetic microspheres, such as morphological, magnetic susceptibility and polymer-drug interactions were characterized by different techniques (i.e. SEM, magnetometry and FT-IR). The loading efficiency and swelling kinetics magnetic microspheres were also studied. The formulated microspheres were below 5μm and spherical in nature as evidenced from SEM. FT-IR revealed that, there was no drug-polymer interaction. The in-vitro release profile was studied in normal saline medium up to 7 hours using USP XXII dissolution apparatus. Drug release in the first hour was found to increase and reached a maximum, releasing approximately 57.46% to 81.44% of the total drug content from the microspheres within 7 hours. A third order equation for the drug release was also calculated. Microspheres showed greater retention time under the influence of magnetic field created by an electromagnet with field strength 8000 G, when compared to the retention in the absence of magnetic field. From this study, it could be suggested that magnetic ethyl cellulose microspheres could be retained at their target site in-vivo, following the application of the magnetic field and are being capable of releasing the drug for an extended period of time, thus making them a suitable depot for delivering chemotherapeutic agent in-vivo.

Pharmacogenomics are very important and refers to drug discovery based on knowledge of genes, but it is a discipline that offers insight into aetiologic mechanisms, and possible prevention and treatment.