PREPARATION AND IN VITRO EVALUATION OF DICLOFENAC SODIUM LOADED ETHYL CELLULOSE COMPOSITE MAGNETIC MICROSPHERES

Vimal Kumar Varma M.¹, Amareshwar P.², Hemamalini K.³, Sreenivas K.⁴, Anwesh Babu K.⁵, Kranthi K.^6
1University College of Technology, Dept of Pharmaceuticals and Fine chemicals, Osmania University, Hyderabad 500 007, AP, India
²University College of Technology, Dept of Pharmaceuticals and Fine chemicals, Osmania University, Hyderabad 500 007, AP, India
³University College of Technology, Dept of Pharmaceuticals and Fine chemicals, Osmania University, Hyderabad 500 007, AP, India
⁴Dept of Pharmaceutics, Mother Teresa College of Pharmacy, Ghatkeser, R.R. Dist 501301, AP, India
⁵Dept of Pharmaceutics, Mother Teresa College of Pharmacy, Ghatkeser, R.R. Dist 501301, AP, India
⁶Dept of Pharmaceutics, Mother Teresa College of Pharmacy, Ghatkeser, R.R. Dist 501301, AP, India

Received : -     Accepted : -     Published : 21-12-2009
Volume : 1     Issue : 2       Pages : 40 - 45
Int J Pharmaceut Anal 1.2 (2009):40-45
DOI : http://dx.doi.org/10.9735/0975-3079.1.2.40-45

Keywords : Emulsion-Solvent evaporation technique, Ethyl cellulose, Diclofenac sodium, Magnetite, Electromagnet, Magnetic microspheres, Magnetometry, Magnetically modulated drug delivery systems
Conflict of Interest : None declared

In this study Diclofenac sodium-containing ethyl cellulose micro particles were prepared by the Emulsion-solvent evaporation method with a view for use in the application of magnetic carrier technology. The properties of these magnetic microspheres, such as morphological, magnetic susceptibility and polymer-drug interactions were characterized by different techniques (i.e. SEM, magnetometry and FT-IR). The loading efficiency and swelling kinetics magnetic microspheres were also studied. The formulated microspheres were below 5μm and spherical in nature as evidenced from SEM. FT-IR revealed that, there was no drug-polymer interaction. The in-vitro release profile was studied in normal saline medium up to 7 hours using USP XXII dissolution apparatus. Drug release in the first hour was found to increase and reached a maximum, releasing approximately 57.46% to 81.44% of the total drug content from the microspheres within 7 hours. A third order equation for the drug release was also calculated. Microspheres showed greater retention time under the influence of magnetic field created by an electromagnet with field strength 8000 G, when compared to the retention in the absence of magnetic field. From this study, it could be suggested that magnetic ethyl cellulose microspheres could be retained at their target site in-vivo, following the application of the magnetic field and are being capable of releasing the drug for an extended period of time, thus making them a suitable depot for delivering chemotherapeutic agent in-vivo.

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