Gomase V.S.1, Ramu Akella2
1Department of Biotechnology, Padmashree Dr. D.Y. Patil University, Navi Mumbai, 400614, India
2Department of Biotechnology, Padmashree Dr. D.Y. Patil University, Navi Mumbai, 400614, India
Received : - Accepted : - Published : 21-12-2009
Volume : 1 Issue : 2 Pages : 31 - 36
Int J Pharmaceut Anal 1.2 (2009):31-36
DOI : http://dx.doi.org/10.9735/0975-3079.1.2.31-36
Keywords : phosphorylation, enrichment, chemical modification, SILAC, mass spectrometry, HILIC
Conflict of Interest : None declared
Post-genomic biology seeks identification and quantification of multiple proteins from complex mixtures and the research is still on. Despite recent progress in high-throughput proteomics, proteomic analysis of post-translationally modified [PTM] proteins remains particularly challenging. Several strategies for isolating phosphoproteins are explored herein. Quantification of phosphoproteins seems to be a novel solution to identify the underlying disease mechanisms, mostly cancer.
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