MALIGNANT TRICHOEPITHELIOMA IN ENGLISH MASTIFF DOG: A CASE REPORT

R.S. PARMAR¹*, K.A. DESAI², J.D. ODEDARA³, G.D. DESAI⁴, P.G. SOLANKI⁵, R.K. JAIN⁶, P.I. SINDHI⁷, D.M. CHAUDHARY⁸, D.K. PATEL^9
1Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
²Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
³Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
⁴Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
⁵Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
⁶Department of Veterinary Surgery & Radiology, College of Veterinary Science & Animal Husbandry, Mhow, 453446, Nanaji Deshmukh Veterinary Science University, Jabalpur, 482001, Madhya Pradesh, India
⁷Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
⁸Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
⁹Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
* Corresponding Author : drrohit.vet23@gmail.com

Received : 07-11-2022     Accepted : 28-11-2022     Published : 30-11-2022
Volume : 14     Issue : 11       Pages : 11908 - 11910
Int J Agr Sci 14.11 (2022):11908-11910

Keywords : Trichoepithelioma, Malignant, Hair Follicle, Dog, Ki-67
Academic Editor : Dr Prashant Shrivastava
Conflict of Interest : None declared
Acknowledgements/Funding : Authors are thankful to Department of Veterinary Surgery & Radiology; Department of Veterinary Pathology, College of Veterinary Science & Animal Husbandry, Sardarkrushinagar, 385505, Kamdhenu University, Gandhinagar, 382010, Gujarat, India
Author Contribution : All authors equally contributed

Seven-year-old, 58kg English mastiff dog with history of multiple cutaneous nodules was presented to clinic. The nodules were present predominantly on back, limb and flank region of the body. Of these, the cutaneous nodule on right lower flank region was exophytic, measuring 9.2 cm in diameter and had multi lobulated appearance and ulcerated surface. The mass was excised surgically and the representative tissue sample was submitted for histopathology. Microscopic examination revealed islands of neoplastic cells and cystic structures that showed contiguity with overlying epidermis or follicular infundibulum. The neoplastic cells showed incomplete trichogenesis. The islands of neoplastic cells form variably sized keratin filled cysts and exhibit both gradual and abrupt keratinization. The mitotic figures were 64 per 2.37 square millimeter area. Besides these, the multifocal pyogranulomatous inflammation was also noted in tumor areas while ulceration and acanthosis were also noted in overlying epidermis. Based on microscopic findings the tumor was diagnosed as malignant Trichoepithelioma and confirmation was done by immunohistochemical staining with Ki-67 marker that showed high proliferative index of 54% in tumor hot spot area which further confirm the neoplasm as malignant trichoepithelioma

1. Goldschmidt M.H. and Goldschmidt K.H. (2017) In, Meuten DJ, ed. Tumors in Domestic Animals. 5th ed. Wiley Blackwell, 88-141.
2. Brown T.M., Krishnamurthy K. (2022) In, StatPearls [Internet] Treasure Island (FL), StatPearls Publishing, PMID, 30422524.
3. Graf R., Pospischil A., Guscetti F., Meier D., Welle M. and Dettwiler M. (2018) Veterinary Pathology, 55, 809-820.
4. Kok M.K., Chambers J.K., Tsuboi M., Nishimura R., Tsujimoto H., Uchida K. and Nakayama H. (2019) Journal of Veterinary Medical Science, 24, 81(8), 1133-1143.
5. Wiener D.J. (2021). Journal of Veterinary Diagnostic Investigation, 33(3), 479-497.
6. Mohammadi A.A. and SeyedJafari S.M. (2014) World Journal of Plastic Surgery, 3, 142-145.
7. Abramo F., Pratesi F., Cantile C., Sozzi S. and Poli A. (1999) Journal of Small Animal Practice, 40(10), 479-81.
8. Tavasoli A., Golshahi H., Rad M.N. and Taymouri A. (2013) Asian Pacific Journal of Tropical Biomedicine, 3(5), 413-5.
9. Gross T.L., Ihrke P.J., Walder E.J. and Affolter V.K. (2005) In, Gross T.L., ed. Skin Diseases of the Dog and Cat. 2nd ed. Blackwell Science Ltd, 604-640.
10. Hendrick M.J. (2017) In, Meuten DJ, eds. Tumors in Domestic Animals. Singapore, Wiley Blackwell, 88-141.
11. Goldschmidt M.H., Munday J.S. and Scruggs J.L. (2008) In, Kiupel M., ed. Tumors with Adnexal Differentiation. 3rd ed. Washington, DC, Armed Forces Institute of Pathology, 107-119.
12. Goldschmidt M.H. and Shofer F.S. (1998) In, Goldschmidt MH, Shofer FS, eds. Skin Tumors of the Dog & Cat. Elsevier Health Sciences, pp115-124.
13. Beck A., Huber D. and Scuric V. (2016) Veterinarski arhiv, 86(3), 453-466.
14. Suvarna S.K., Layton C. and Bancroft J.D. (2013). eds. Bancro’s theory and practice of histological techniques. Nottingham and Sheffield, Churchill Livingstone-Elsevier.
15. Hazan C., Melzer K., Panageas, K. S., Li E., Kamino H., Kopf A., Cordon-Cardo C., Osman I. & Polsky D. (2002) Cancer, 95, 634-640.
16. Iqbal S., Anderson T. J. & Marson, L.P. (2002) Breast, 11, 252-256.