STUDY OF AMELIORATIVE EFFECT OF VITAMIN C ON INDOXACARB INDUCED TOXICITY ON HEMATOBIOCHEMICAL PARAMETER IN MALE WISTAR RATS

P.B. RATHOD¹*, J.G. PATEL², S.P. MODH³, S.H. RAVAL⁴, R.S. PARMAR⁵, B.J. PATEL⁶, N.B. BHATI⁷, P.I. SINDHI⁸, K.D. THAKOR⁹, T.R. KUMBHANI^10
1Polytechnic in Animal Husbandry, Kamdhenu University, Rajpur (Nava), Himmatnagar, 383010, India
²Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagr, Dantiwada, 385505, India
³Pathology Laboratory, V Cross Diagnostic Laboratory and Research Centre, Palanpur, Banaskanth, 385001, Gujarat, India
⁴Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagr, Dantiwada, 385505, India
⁵Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagr, Dantiwada, 385505, India
⁶Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagr, Dantiwada, 385505, India
⁷Polytechnic in Animal Husbandry, Kamdhenu University, Rajpur (Nava), Himmatnagar, 383010, India
⁸Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagr, Dantiwada, 385505, India
⁹Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagr, Dantiwada, 385505, India
¹⁰Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagr, Dantiwada, 385505, India
* Corresponding Author : parthrathod750@gmail.com

Received : 02-10-2021     Accepted : 27-10-2021     Published : 30-10-2021
Volume : 13     Issue : 10       Pages : 10902 - 10905
Int J Agr Sci 13.10 (2021):10902-10905

Keywords : Toxicity, Indoxacarb, Ameliorative, Vitamin C, Rats
Conflict of Interest : None declared
Acknowledgements/Funding : Authors are thankful to Principal of College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagr, Dantiwada, 385505 and Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Sardarkrushinagr, Dantiwada, 385505
Author Contribution : All authors equally contributed

This present study was undertaken to determine the ameliorative effect of vitamin C on indoxacarb toxicity. For this purpose, 20 male Wistar rats were randomly divided into four different groups as I to IV. Group I, II, III and IV received vehicle (control), IND (173.2 mg/kg b.wt.), VIT-C (200 mg/kg b.wt.) and IND+VIT-C (173.2 mg/kg b.wt. IND + 200 mg/kg b.wt. VIT-C) by oral gavages daily for 28 days. There was significantly (P < 0.05) decreased in TEC, Hb and HCT values of Groups II (IND) and IV (IND+VIT-C) rats when compared with control rats. The rats of Groups II and IV revealed significant decrease (P < 0.05) triglyceride level when compared with Group I (CMC) and Group III (VIT-C) rats. The rats of Groups II (IND) and IV (IND+VIT-C) showed significant (P < 0.05) increase in total antioxidant status in comparison to control Group rats. Ameliorative effect of vitamin C was observed on haematology and biochemical alterations in indoxacarb intoxicated rats

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