The effect of Vitamin E (1 mmol/kg body weight/day given intraperitoneally for 7 days before the administration of benzene) on benzene (500 mg/kg body weight/day in corn oil) induced alterations of some enzymes of carbohydrate metabolism and oxidative stress in rat liver was investigated. Control group was give only corn oil. Each treatment was carried out for 20 days. Results revealed that administration of benzene caused a significant increase in the levels of lactate dehydrogenase (LDH), Lipid peroxidation and malondialdehyde (MDA). Whereas the levels of glucose–6 phosphatase, reduced glutathione (GSH) superoxide dismutase (SOD) and Catalase were significantly decreased compared to control animals. But in those animals which received Vitamin E therapy 7 days before being challenged with benzene, the changes in those parameters were almost statistically non-significant. This study indicated that, Vitamin E, a well known antioxidant can protect the major profiles of Carbohydrate metabolism and normal oxidative state of liver from the detrimental effects of benzene at this concentration.

The redox characteristics of the drug Bicalutamide at a glassy-carbon electrode (GCE) was investigated for the first time in aqueous media by differential-pulse voltammetry (DPV) and cyclic voltammetry (CV). In Britton–Robinson (BR) buffer of pH 2.0–10.0, an irreversible and diffusion-controlled reduction voltagram were developed. The dependence of the CV response of the developed cathodic peak on the sweep rate (
) and on depolarizer concentration was typical electrode-coupled chemical reaction mechanism (EC) in which an irreversible reaction is interposed between the charges. In BR buffer of pH 6 - 7, a well defined cathodic peak was developed and the plot of peak current height of the DPV against Bicalutamide concentration at this peak potential was linear in the range 1×10−8– 2.6 ×10−5 M with lower limits of detection (LOD) and quantization (LOQ) of 8 x 10-8 M and 1 ×10−7 M, with good selectivity and sensitivity. A relative standard deviation (RSD) for Bicalutamide at a concentration of 4.5×10−5 M was 2.48% (n=6). The proposed method was successfully applied to Bicalutamide determination in pharmaceutical samples and results are very good correlations with previously reported methods.

Some novel organic amides were synthesized by the reaction of glycine/cystiene and ethylene diamine with respective organic acids (succinic acid, maleic acid, tartaric acid and oxalic acid). The newly synthesized compounds were isolated as crystalline solid and have sharp melting point. The compounds were characterized by their elemental, I.R., NMR spectral analysis along with their activity against an insect responsible for the damage of Indian crops Spodoptera litura. It was found that the compounds show moderate efficacy against the insect.