Electrochemical behavior and differential pulse voltametric determination of an antineoplastic drug bicalutamide and pharmaceuticals formulations using glassy carbon electrode

Raghu K.¹*, Chandrasekar A.², Sankaran K.R.^3
1Department of Chemistry, Krishnasamy College of Engineering & Technology, Cuddalore, 607109, India
²Shasun Chemicals and drugs Ltd, Cuddalore, 607005, India
³Department of Chemistry, Annamalai University, Annamalai Nagar, 608002, India
* Corresponding Author : ragukpatham@gmail.com

Received : -     Accepted : -     Published : 21-12-2010
Volume : 2     Issue : 2       Pages : 5 - 16
Int J Chem Res 2.2 (2010):5-16
DOI : http://dx.doi.org/10.9735/0975-3699.2.2.5-16

Keywords : Bicalutamide, Glassy carbon Electrode, Britton Robinson Buffer, Cyclic Voltammetry and Differential Pulse Voltammetry
Conflict of Interest : None declared

The redox characteristics of the drug Bicalutamide at a glassy-carbon electrode (GCE) was investigated for the first time in aqueous media by differential-pulse voltammetry (DPV) and cyclic voltammetry (CV). In Britton–Robinson (BR) buffer of pH 2.0–10.0, an irreversible and diffusion-controlled reduction voltagram were developed. The dependence of the CV response of the developed cathodic peak on the sweep rate (
) and on depolarizer concentration was typical electrode-coupled chemical reaction mechanism (EC) in which an irreversible reaction is interposed between the charges. In BR buffer of pH 6 - 7, a well defined cathodic peak was developed and the plot of peak current height of the DPV against Bicalutamide concentration at this peak potential was linear in the range 1×10−8– 2.6 ×10−5 M with lower limits of detection (LOD) and quantization (LOQ) of 8 x 10-8 M and 1 ×10−7 M, with good selectivity and sensitivity. A relative standard deviation (RSD) for Bicalutamide at a concentration of 4.5×10−5 M was 2.48% (n=6). The proposed method was successfully applied to Bicalutamide determination in pharmaceutical samples and results are very good correlations with previously reported methods.

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