Synthesis of some new amides and their toxicological effect on an insect Spodoptera litura

Saxena C.M.¹*, Singh R.K.², Sanjay Ashthana³, Archna Saxena^4
1Research Laboratory; Department of Chemistry, D.B.S. P.G. College, Kanpur, India
²Research Laboratory; Department of Chemistry, D.B.S. P.G. College, Kanpur, India
³Research Laboratory; Department of Chemistry, D.A.V. P.G. College, Kanpur, India
⁴Research Laboratory; Department of Chemistry, D.B.S. P.G. College, Kanpur, India
* Corresponding Author : drcmsaxena01@gmail.com

Received : -     Accepted : -     Published : 21-12-2010
Volume : 2     Issue : 2       Pages : 17 - 20
Int J Chem Res 2.2 (2010):17-20
DOI : http://dx.doi.org/10.9735/0975-3699.2.2.17-20

Keywords : Glycine, ethylenediamine, succinic acid, maleic acid, oxalic acid, tartaric acid, insecticidal activity, Spodoptera litura
Conflict of Interest : None declared
Acknowledgements/Funding : The authors are highly thankful to the Director, RSIC CDRI Lucknow for elemental analysis, I.R. and NMR spectral analysis and Director, NBRI for insecticidal activity

Some novel organic amides were synthesized by the reaction of glycine/cystiene and ethylene diamine with respective organic acids (succinic acid, maleic acid, tartaric acid and oxalic acid). The newly synthesized compounds were isolated as crystalline solid and have sharp melting point. The compounds were characterized by their elemental, I.R., NMR spectral analysis along with their activity against an insect responsible for the damage of Indian crops Spodoptera litura. It was found that the compounds show moderate efficacy against the insect.

[1] Springborg J. and Satofte I. (1997) Acta.chem.Scaud 51, 357  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[2] Varngy J. (2000) J. Chem. Soc. Dalton. Trans 467  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[3] Georgina R.L.A.;Blanka R.D.E. and Marta Depareco M.R. (1975) Bio,chem. Pharmacol, 24, 2307  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[4] Saxena A., Kochar J.K. and Tandon J.P. (1981) J. Antribact. Antifungal Agents, 9, 435  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[5] Giri S. and Khare R.K. (1976) J. Antibact. Antifungal Agents 4, 4  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[6] Dhar D.N. and Taploo C.L. (1982) J.Sci.Ind. Res. 41, 501  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[7] Sandhar R.K.; Sharma J.R. and Manrao M.R. (2005) Pesti. Res. 17, 9  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[8] Rai M.K.; Kaul V.K.and Sharma J.R. (2006) J. Ind. Chem. Soc. 83, 208  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[9] Ledmicer D.and Mitschen L.A. (1980) The Organic drug Synthesis; John Wiley and Sons, Inc. New York 2, 248  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[10] Delegado J.N. and Remers W.A. (2004) In Wilson and Gisvold’s, Text book of organic Medicinal and pharmaceutical chemistry, Lippin.Catt.Raven Philadelphia, 204.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[11] Kant Ravi, Amresh, Chandrasekhar K. and Anil Kumar K.S. (2008) Phosphorous, Sulfur and Silicon, 183, 1410.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[12] Kant Ravi, Shukla S.K., Singhal K., Chandrashekar K., Saxena A.K., Ranjan A. and Raj P. (2008) Phosphorus, Sulfur, Silicon, 183, 2029.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[13] Deshmukh S.D., Borle M.N. (1976) Ind. J. Entomol, 37(1), 11-18  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[14] Bhonde S.P., Kapadnis B.P., Deshpande S.P., Sharma R.N. (2001) J. Med. Arona Plant., 24, 721- 725  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus