Epilepsy is a neurological disorder. About 0.5%-1% of world population is affected by epilepsy. Petit mal epilepsy is the main seizure type in 15-20% of epileptic children. The mainstream intervention for petit mal epilepsy is T-type Ca ++ channel blocker like ethosuximide. However, there is a need for safer and effective drug. The protein-ligand interaction plays a significant role in structure based drug designing. In the present work we have taken t-type calcium channel as the target and identified natural compounds that can be used against petit mal epilepsy. Here the drug ethosuximide is used as standard (E value = -132.35). Twelve natural compounds are retrieved from PubMed and are checked for drug likeness with bioinformatics tool ADMETox to satisfy Lipinski’s rule of five. Ten natural drugs qualify this step and are docked with receptor using HEX docking software. All the compounds taken for docking were found to be better than the conventional drug, Ethosuximide.

The study was carried out to ascertain the hepatoprotective activity of traditional ayurvedic formulation ‘Vidakana Choornam’ against carbon tetrachloride induced hepatotoxicity in albino rat. Effect of carbon tetrachloride and herbal products on liver weights was studied. Bilirubin level in serum, Serum Glutamate Pyruvate Transaminase (GPT) level in serum, Serum Glutamate Oxaloacetate Transaminase (GOT) level in serum and ALP level in serum were estimated in both control treatment. Histopathological studies were also carried out. It was found that there was an increase in liver weight during carbon tetrachloride treatment which may be due to accumulation of fat. The results of Vidakana Choornam’ treatment against carbon tetrachloride induced hepatotoxicity revealed that there was considerable reduction in Bilirubin level in serum, Serum Glutamate Pyruvate Transaminase (GPT) level in serum, Serum Glutamate Oxaloacetate Transaminase (GOT) level in serum and ALP level in serum. The hepatoprotective activity of this simple formulation was found to be as effective as Liv – 52, infact the activity on decreasing the serum bilirubin level was much higher when compared to Liv – 52.