STUDIES ON HEPATOPROTECTIVE ACTIVITY OF TRADITIONAL AYURVEDIC FORMULATION ‘VIDAKANA CHOORNAM’ AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN ALBINO RAT

Jayarama Reddy¹, Gnanasekaran D.², Vijay D.³, Ranganathan T.V.^4
1St. Joseph’s Post graduate and Research Centre, 36, Langford Road, Bangalore-560027
²Bharati College of Pharmacy, Bharati Nagara, Mandya, Karnataka
³Research Department of Plant Biology and Biotechnology, Arignar Anna Government Arts College, Viluppuram, Tamil Nadu
⁴St. Joseph’s Post graduate and Research Centre, 36, Langford Road, Bangalore-560027

Received : -     Accepted : -     Published : 21-12-2010
Volume : 2     Issue : 2       Pages : 5 - 16
Int J Pharmaceut Anal 2.2 (2010):5-16
DOI : http://dx.doi.org/10.9735/0975-3079.2.2.5-16

Keywords : Vidakana Choornam, Bilirubin, Serum Glutamate Pyruvate Transaminase, Glutamate Oxaloacetate Transaminase, ALP level, hepatoprotective, Histopathology.
Conflict of Interest : None declared

The study was carried out to ascertain the hepatoprotective activity of traditional ayurvedic formulation ‘Vidakana Choornam’ against carbon tetrachloride induced hepatotoxicity in albino rat. Effect of carbon tetrachloride and herbal products on liver weights was studied. Bilirubin level in serum, Serum Glutamate Pyruvate Transaminase (GPT) level in serum, Serum Glutamate Oxaloacetate Transaminase (GOT) level in serum and ALP level in serum were estimated in both control treatment. Histopathological studies were also carried out. It was found that there was an increase in liver weight during carbon tetrachloride treatment which may be due to accumulation of fat. The results of Vidakana Choornam’ treatment against carbon tetrachloride induced hepatotoxicity revealed that there was considerable reduction in Bilirubin level in serum, Serum Glutamate Pyruvate Transaminase (GPT) level in serum, Serum Glutamate Oxaloacetate Transaminase (GOT) level in serum and ALP level in serum. The hepatoprotective activity of this simple formulation was found to be as effective as Liv – 52, infact the activity on decreasing the serum bilirubin level was much higher when compared to Liv – 52.

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