Immunoinformatics utilizes bioinformatics applications such as immune related databases with integration of mathematics, information science, computer engineering, genomics, proteomics which bridge immunology and informatics. Plants lack adaptive immune system and rely on innate immunity which consists of many protein interactions, which protect them from infections. The plant innate immunity consists of many molecular switches that help in activation of plant innate immunity. The plant innate immunity also consists of many elicitors and suppressors that elicit and suppress the plant innate immunity respectively. Fragment-based drug discovery is a new approach that builds drugs from small chemical structures.

Soil-borne microorganisms can induce an enhanced defensive capacity in above-ground plant parts, which provides protection against a broad spectrum of microbial pathogens; even insect herbivores and emerged as important regulators of this induced systemic resistance.

The prevalence of HIV /AIDS in Indian population has been carried out. However analysis of secondary infection after HIV is carried out by the present studies. A total of 58 patients suffering from HIVAIDS were analyzed with reference to the age, gender, BMI and Mode of infection. Data analysis showed that patients suffering from HIV / AIDS have greater risks of Tuberculosis disorders. A distinct correlation between Tuberculosis and HIV/ AIDS was observed during the present studies.

The synthesis of 2-Phenyl-3,1-benzoxazine-4-one 1 have been obtained from Antharanilic acid by stirring in dry pyridine at room temperature. The compound 1 are then converted to their respective quinazolone 2 by treatment with hydrazine hydrate and Compound 3 by treatment with 1,1-biphenyl-4,4-diamine. The compound 4&5 on heating with aromatic aldehyde to give 3-(p-Arylidenoamino diphenyl)/2-Phenyl-3-arylidene-amino-4-(3H) quinazolone. Interaction of compound 4&5 with thioglycollic acid undergoes cyclization to give3-(p-Arylidenoamino diphenyl)/2-Phenyl-3-{3'-(2-aryl-4-oxo-1',3'-l)]quinazolones. The in vitro anti-JEV activity of these compounds has also been evaluated.