SYNTHESIS OF THIAZOLYL QUINAZOLONES FOR STUDYING THEIR ANTIVIRAL ACTIVITY AGAINST JAPANESE ENCEPHALITIS VIRUS (JEV), A RNA VIRUS OF HIGH PATHOGENICITY

Krishna Srivastava^1
1Sri. Ramswaroop Memorial College of Engg. & Mgmt, Faizabad Road, Lucknow-227105

Received : -     Accepted : -     Published : 21-12-2009
Volume : 1     Issue : 2       Pages : 19 - 23
Int J Parasitol Res 1.2 (2009):19-23
DOI : http://dx.doi.org/10.9735/0975-3702.1.2.19-23

Keywords : quinazolone, 1,1-biphenyl-4,4-diamine, dimethylformamide (DMF), thioglycollic acid, Antharanilic acid
Conflict of Interest : None declared
Acknowledgements/Funding : The authors express their sincere thanks to Prof. A. Khare, Head, Department of Chemistry, Lucknow University, Lucknow for providing Laboratory facilities.They are also thankful to the Director,CDRI,Lucknow for elemental,spectral and biological data

The synthesis of 2-Phenyl-3,1-benzoxazine-4-one 1 have been obtained from Antharanilic acid by stirring in dry pyridine at room temperature. The compound 1 are then converted to their respective quinazolone 2 by treatment with hydrazine hydrate and Compound 3 by treatment with 1,1-biphenyl-4,4-diamine. The compound 4&5 on heating with aromatic aldehyde to give 3-(p-Arylidenoamino diphenyl)/2-Phenyl-3-arylidene-amino-4-(3H) quinazolone. Interaction of compound 4&5 with thioglycollic acid undergoes cyclization to give3-(p-Arylidenoamino diphenyl)/2-Phenyl-3-{3'-(2-aryl-4-oxo-1',3'-l)]quinazolones. The in vitro anti-JEV activity of these compounds has also been evaluated.

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