| Title |
THE ASSOCIATION BETWEEN TMPRSS2 GENETIC POLYMORPHISMS AND THE SUSCEPTIBILITY AND SEVERITY OF COVID-19: A SYSTEMATIC REVIEW |
| | Genetics Vol:14 Iss:4 (2022-10-30) : 850-855 |
| Authors |
C.S. SILVA, M.J.A. SILVA, K.V.B. LIMA, C.C. FROTA, D.M. SARDINHA, L.N.G.C. LIMA |
| Published on |
30 Oct 2022 Pages : 850-855 Article Id : BIA0006110 Views : 35 Downloads : 96 |
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Abstract |
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Open Access | Review Article
COVID-19, caused by the SARS-CoV-2 virus, is a highly transmissible disease that has a variety of symptoms. The presence of genetic polymorphisms in genes as ACE-2 and TMPRSS2 is directly associated with the susceptibility and severity of COVID-19. The objective of this work is to analyze which polymorphisms in the TMPRSS2 gene are associated with the progression of COVID-19. We identified 35 SNPs associated with disease progression. The high expression of TMPRSS2 in the lungs was associated with the presence of polymorphisms such as rs383510, rs469390 and rs464397. rs12329760 was the polymorphism most studied, where the presence of the T allele was related to protection against COVID-19. The SNPs found play an important role in determining the prognosis of the disease
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