| Title |
STUDY OF THE IL-23 RECEPTOR AND THE IL-28B GENE POLYMORPHISM IN INDIVIDUALS FROM THE LEPROSY-ENDEMIC AREA IN THE BRAZILIAN AMAZON |
| | Genetics Vol:14 Iss:1 (2022-05-30) : 833-839 |
| Authors |
A.L.deS. GONCALVES, L.S. MOURA, M.E.S.de CARVALHO, E.C.dos SANTOS, M.doP.S.C.A. SILVESTRE, A.B. SOUZA, E.P.daC. GURRAO, M.J.A. SILVA, K.V.B. LIMA, L.N.G.C. LIMA |
| Published on |
30 May 2022 Pages : 833-839 Article Id : BIA0005944 Views : 198 Downloads : 147 |
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Leprosy is an immunopathology caused by Mycobacterium leprae and its clinical evolution depends on the immunological aspects of the host. There is evidence that IL28B acts by activating TNK cells and IL-23 promotes the expansion of Th17 cells, both actions are fundamental in the response to mycobacteria. We verified the relationship between the rs12979860 polymorphism in the IL28B gene and the rs11209026 polymorphism in the IL23 receptor gene and leprosy. 240 individuals from the Brazilian Amazon were included in the research, from which blood samples were collected for DNA extraction, SNP typing and sequencing. Individuals between 32 and 46 years old had 7.6 and individuals over 46 years old were 12.4 times more likely to become patients. No associations were observed between the rs12979860 SNP in the IL28B gene and the rs11209026 SNP in the IL23R, their genotypes and alleles and leprosy
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