Wound casualties are encountered very often in various situations including combat scenario. All these wounds need to be healed rapidly and efficiently to bring back the injured individual to an optimum level of fitness so that he can get back to his normal work schedule. So far, many strategies have been developed across the globe. But there is a no infallible solution available that can overcome the various complexities in wound healing and its management. Hence, there is a need to develop suitable technologies that could solve wound related complexities. An ideal intervention for wound care must involve components that act the different steps in the process of natural wound healing. An ideal intervention should possess blood-clotting, anti-microbial, growth promoting and analgesic properties. The present review briefly discusses the current understanding and future prospect of wound healing.

p53 is a protein that induces apoptosis when DNA damage occurs. A mutated p53 protein involves in more than 50% of human cancers and possesses a role in breast cancer formation. Investigation for finding potential candidates anticancer drug that causes minimal side effects are generally obtained from nature, and sea sponges are currently explored. The purpose of this study was to determine a docking score and amino acids that play a role in an activity of alkaloid compounds from selected sponges Cinachyrella anomala SA2014 against protein p53. SA2014 compound has the ability as anticancer compounds against breast cancer T47D through the interaction of the amino acid leucine and phenylalanine. Leucine plays a role in the binding of p53 with SA2014 alkaloid compound that affected a resistance of cell cycle at G1 phase / S and triggered apoptosis. Furthermore, Phenylalanine stabilized p53 tetrameric structure through hydrogen bonds.