Orthoester Johnson-Claisen rearrangement is a very powerful C-C bond forming reaction. Its precise region-selectivity, high level of stereo-selectivity and opportunity of stereo-control makes this reaction as a very useful tool in organic synthesis. Over last few years this reaction has been widely explored towards the synthesis of a varied range of natural products, bioactive molecules, synthetic intermediates and chemically modified valuable materials. Recent development in this rearrangement and applications since 2010 is presented in this review article.