RECENT DEVELOPMENT IN THE ORTHOESTER JOHNSON-CLAISEN REARRANGEMENT AND APPLICATION

ALAM SAFIUL¹*
¹Department of Chemistry, Aliah University, IIA/27, New Town, Kolkata, 700156, West Bengal, India
* Corresponding Author : safiul_ku@yahoo.co.in

Received : 07-04-2016     Accepted : 11-05-2016     Published : 21-05-2016
Volume : 8     Issue : 2       Pages : 173 - 194
Int J Chem Res 8.2 (2016):173-194

Keywords : Oxy-Claisen rearrangement, Regioselectivity, Stereoselective synthesis, Catalysis, Sequential Claisen rearrangement, Exo-pericyclic stereocontrol, Bioactive molecules, Natural products
Academic Editor : Dr Santosh Balasaheb Kamble
Conflict of Interest : None declared
Acknowledgements/Funding : SA is thankful to the Department of Science and Technology (DST), New Delhi, India for providing research funding (SB/FT/CS-066/2013) and Aliah University, Kolkata, for providing research facilities.
Author Contribution : None declared

Orthoester Johnson-Claisen rearrangement is a very powerful C-C bond forming reaction. Its precise region-selectivity, high level of stereo-selectivity and opportunity of stereo-control makes this reaction as a very useful tool in organic synthesis. Over last few years this reaction has been widely explored towards the synthesis of a varied range of natural products, bioactive molecules, synthetic intermediates and chemically modified valuable materials. Recent development in this rearrangement and applications since 2010 is presented in this review article.