BACTERIOLOGICAL PROFILE AND ANTIBIOGRAM OF UROPATHOGENS AT TERTIARY CARE CENTRE

VANI MAJJI¹*
¹Consultant Microbiologist, KIMS Hospital Enterprises Pvt.Ltd., Kondapur, Hyderabad, 500084, Telangana, India
* Corresponding Author : vani.m@kimshospitals.com

Received : 01-06-2023     Accepted : 27-06-2023     Published : 30-06-2023
Volume : 15     Issue : 2       Pages : 2012 - 2015
Int J Microbiol Res 15.2 (2023):2012-2015

Keywords : Urinary tract infections, Antibiogram, E.coli, K. pneumoniae, Enterococcus
Academic Editor : Reddypriya Pasupuleti, , Kumar D Shiva, V. C. Ingle
Conflict of Interest : None declared
Acknowledgements/Funding : Author is thankful to KIMS Hospital Enterprises Pvt.Ltd., Kondapur, Hyderabad, 500084, Telangana, India
Author Contribution : Sole Author

Background: Urinary tract Infections (UTIs) are a cause of significant morbidity and mortality requiring urgent antibiotic treatment. However, there is widespread antibiotic-resistance from the bacterial causes, necessitating regular surveillance for drug-resistant bacteria and their antibiograms. Objective: The aim of this study is to isolate and identify various bacterial causes of UTIs and determine their antibiotic susceptibility patterns. Methods: A total of 5017 urine samples were analyzed from January 2021 to December 2022. Out of these 1014 samples were positive. Identification of the pathogen and antimicrobial sensitivity were done using the Automated system, Vitek 2 compact (Biomereiux). Results: Culture positivity in this study was 20%. Gram-negative bacteria were predominantly isolated (79.7%), including Escherichia coli (52.8%) and Klebsiella aerogenes (14.2%). Enterococcus faecalis was the most common Gram-positive bacterium isolated. Antibiotic susceptibility pattern among gram negative bacilli has shown maximum sensitivity to Colistin, Fosfomycin, followed by Carbapenems (Imipenem, Meropenem & Ertapenem), Amikacin and Beta lactam- betalactam inhibitor (BL-BLI) combination drugs. Out- patient department (OPD) samples were found to be more susceptible to antimicrobials than In-patient department (IPD) samples. Maximum resistance was seen against Ciprofloxacin and Ceftriaxone. Klebsiella and Pseudomonas isolates were found to be more resistant when compared to E.coli. E.coli isolates were more sensitive to Nitrofurantoin (87%) than Klebsiella (22%). Carbapenem resistance was seen in 50% of the Inpatient isolates of Klebsiella and 36% of Inpatient isolates of Pseudomonas.Few isolates of Klebsiella and Pseudomonas were found to be resistant even to Colistin

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