INCIDENCE OF HIV, HEPATITIS B AND HEPATITIS C INFECTION AMONG PATIENTS UNDERGOING DIALYSIS

A.H. AMER¹*, R. PATEL², R. TRIVEDI³, K. CHAUDHARI⁴, P. TRIVEDI^5
1Pramukhswami Medical College, Karamsad, Anand, 388325, Sardar Patel University, Anand, 388325, Gujarat, India
²Pramukhswami Medical College, Karamsad, Anand, 388325, Sardar Patel University, Anand, 388325, Gujarat, India
³Pramukhswami Medical College, Karamsad, Anand, 388325, Sardar Patel University, Anand, 388325, Gujarat, India
⁴Pramukhswami Medical College, Karamsad, Anand, 388325, Sardar Patel University, Anand, 388325, Gujarat, India
⁵Senior Application Specialist, Roche Diagnostics India Pvt. Ltd., Gujarat, India
* Corresponding Author : hefdhallaha@yahoo.com

Received : 16-08-2019     Accepted : 26-10-2019     Published : 30-10-2019
Volume : 11     Issue : 10       Pages : 1712 - 1714
Int J Microbiol Res 11.10 (2019):1712-1714

Keywords : Dialysis, HIV, Hepatitis B virus, Hepatitis C virus
Academic Editor : Dr Manodeep Sen
Conflict of Interest : None declared
Acknowledgements/Funding : Authors are thankful to Shree Krishna Hospital, Karamsad and Pramukhswami Medical College, Karamsad, Anand, 388325, Sardar Patel University, Anand, 388325, Gujarat, India.
Author Contribution : All authors equally contributed

Background: Dialysis modality is a major risk factor for HIV, HBV and hepatitis C virus infections. High accuracy quality control has a positive effect in preventing infection. The haemodialysis environment has been recognized as a reservoir for viral infection, and transmission of the virus to patients as well as to staff members. Aim: The aim of this study was to evaluate the effect of dialysis modality on the prevalence of HIV, HBV and HCV infections in patients subjected to dialysis. Material and methods: The study included all dialysis patients who attended the dialysis center at Shri Krishna Hospital, Karamsad, during the period from January 2018 to December 2018. The total patients during this period were 250. HIV, HCV and HBsAg were determined on ADVIA Centaur® XP Immunoassay Analyser by Chemiluminescence Methods. Serum samples were collected according to the routine protocol used in the biochemistry department. Data subjected to computer analysis computer-analyzed using (SPSS 20.USA) program. Reference management was done by Endnote X7 program. Results: This study considered the total number of patients undergoing haemodialysis and the percentage of HIV, Hepatitis B and C infections. In addition, HCV infection among dialysis patients is associated with an increased risk of death. Our study was conducted on a total of 250 patients who underwent dialysis in 2018. In the first screening of dialysis patients, we found 5 patients (2%) out of 250 patients had HCV positive, 245 (98%) of patients were HCV negative. But six months later, the infection percentage was up to 9 patients (3.6%) positive out of 250 patients and 241 (96.4%) had negative HCV. Also, in the first examination of dialysis patients, we found that all patients had negative HBsAg. But after six months, we found 1 (0.4%) out of the 250 patients had positive HBsAg and 249 (99.6%) of the patients had HBsAg negative. Conclusion: The main conclusions of the current study are that the prevalence of hepatitis B virus infection increased with long-term dialysis, and that hepatitis C virus infection was the most prevalent among patients with longer dialysis.

1. Perz J.F., Armstrong G.L., Farrington L.A., Hutin Y.J., Bell B.P. (2006) Journal of Hepatology, 45(4), 529-38.
2. Malhotra R., Soin D., Grover P., Galhotra S., Khutan H., Kaur N. (2016) Journal of Natural Science, Biology, and Medicine, 7(1), 72.
3. Pereira B.J., Natov S.N., Bouthot B.A., Murthy B., Ruthazer R., Schmid C.H., et al. (1998) Kidney International, 53(5),1374-81.
4. Espinosa M., Martin?Malo A., de Lara M.A.A., Aljama P. (2001) Nephrology Dialysis Transplantation,16(8),1669-74.
5. Di Napoli A., Pezzotti P., Di Lallo D., Petrosillo N., Trivelloni C., Di Giulio S., et al. (2006) American Journal of Kidney Diseases, 48(4), 629-37.
6. Fabrizi F., Takkouche B., Lunghi G., Dixit V., Messa P., Martin P. (2007) Journal of Viral Hepatitis, 14(10), 697-703.
7. Josselson J., Kyser B.A., Weir M.R., Sadler J.H. (1987) American Journal of Kidney Diseases, 9(6), 456-61.
8. Jha R., Kher V., Naik S., Elhence R. (1993) Journal of Nephrology, 6, 98.
9. Kwon E., Cho J.H., Jang H.M., Kim Y.S., Kang S.W., Yang C.W., et al. (2015) PloS one,10(8), e0135476.
10. Anwar K., Imran M., Shahzad F., Noreen M., Atif M. (2016) Journal of Human Virology and Retrovirology, 3(3).
11. Abdel-Moneim A.S., Bamaga M.S., Shehab G.M., Abu-Elsaad A.A.S., Farahat F.M. (2012) PloS one,7(1), e29781.
12. Daugirdas J.T., Blake P.G., Ing T.S. (2012) Handbook of dialysis. Fourth Edition ed, Lippincott Williams & Wilkins, 2012.
13. Alter M.J., Favero M.S., Maynard J.E. (1986) Journal of Infectious Diseases, 153(6),1149-51.
14. Alashek W.A., McIntyre C.W., Taal M.W. (2012) BMC Infectious Diseases,12(1),265.
15. Malhotra R., Soin D., Grover P., Galhotra S., Khutan H., Kaur N. (2016) Journal of Natural Science, Biology, and Medicine,7(1),72.
16. Hamissi J., Hamissi H. (2011) International Journal of Collaborative Research on Internal Medicine & Public Health, 3(1),89.