ISSN : 0975-2862
EISSN : 0975-9158
MANISH KUMAR1*, MANPREET KAUR2
1Division of Vegetable Sciences, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India
2Division of Vegetable Sciences, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India
* Corresponding Author : imanishkumar91@gmail.com
Received : 16-03-2018 Accepted : 24-04-2018 Published : 30-04-2018
Volume : 10 Issue : 4 Pages : 394 - 400
Genetics 10.4 (2018):394-400
DOI : http://dx.doi.org/10.9735/0975-2862.10.4.394-400
Keywords : Map-based cloning, Fine mapping, Gene, Molecular marker, Vegetable
Conflict of Interest : None declared
Acknowledgements/Funding : Author thankful to ICAR-Indian Agricultural Research Institute, New Delhi, 110012
Author Contribution : All authors have equally contributed
In the fast-changing world, the trend of vegetable consumption is increasing and molecular science has emerged unequivocally as the leading discipline for its genetic improvement. Cloning of genes governing important traits is one of the main objectives of molecular genetics. The map-based cloning approach has been applied in plant genetics to identify genes having a major effect on the phenotypic variations. Characterizing the causative allelic variation establishes the in vivo function of genes. The basic idea behind map-based cloning is to clone the gene based on knowing its chromosomal location. Map-based cloning or positional cloning refers to the process to recognize the underlying cause of variation in a mutant phenotype without prior assumptions or knowledge of specific genes. For this approach to be successful, a large number of polymorphic markers are required to delimit the gene within a sufficiently small genetic interval of less than 1 cM. Statistical association analyses between molecular polymorphisms of the candidate genes and variation in the trait of interest have also been carried out in a few studies. To validate the gene, physiological analyses, genetic transformation and/or sexual complementation experiments are practiced. A brief summary of fine mapped/cloned genes in vegetable crops is discussed here. The goal of this paper is to present an overview of map-based cloning analyses in plant genetics with special reference to vegetable crops
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