TRICHOSPORONOSIS – AN ASSOCIATION WITH CLINICAL FACTORS AND ITS OUTCOME

T. PREMAMALINI¹*, S.V. RAJYOGANANDH², R. VIJAYAKUMAR³, ANUPMA JYOTI KINDO⁴, S.K. MARAK RUNGMEI^5
1Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai, 600116, Tamil Nadu, India
²Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai, 600116, Tamil Nadu, India
³Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai, 600116, Tamil Nadu, India
⁴Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Chennai, 600116, Tamil Nadu, India
⁵Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
* Corresponding Author : drtpremamalini@gmail.com

Received : 16-03-2018     Accepted : 20-03-2018     Published : 30-03-2018
Volume : 10     Issue : 3       Pages : 1078 - 1082
Int J Microbiol Res 10.3 (2018):1078-1082
DOI : http://dx.doi.org/10.9735/0975-5276.10.3.1078-1082

Keywords : Trichosporonosis, risk factors, indwelling device
Conflict of Interest : None declared
Acknowledgements/Funding : Author thankful to Sri Ramachandra Medical College and Research Institute, Chennai, 600116, Tamil Nadu
Author Contribution : All author equally contributed

Introduction: The genus Trichosporon usually cause superficial mycoses, but recently they have emerged as an important pathogen causing invasive infections in immuno-compromised patients. Invasive Trichosporonosis is mainly documented in patients with associated risk factors and co-morbid conditions like haematological malignancies, cardiac or renal disease, intravenous or central line catheter, prosthetic devices and implants, prior antibiotic therapy, stay in Intensive care unit. Objective: This study was undertaken to assess the risk factors and co-morbid conditions associated with Trichosporonosis and its clinical outcome. Materials and Methods: We considered around 72 clinical isolates for the study that were, dry yeast like colonies, urease positive, showed blastoconidia and arthroconidia in gram stain, and were suspected to belong to the genus Trichosporon. Later, they were confirmed genotypically using Trichosporon specific PCR. The demographic and clinical details were collected from all the patients for the study. Results: About 66% of the affected patients were males, with male to female ratio 2:1. All our patients had any one of associated risk factor. Indwelling catheter was present in most of the patients (97.2%) in our study. Bladder catheterisation was the predominant risk factor among patients who grew Trichosporon sp. in urine sample (83.7%). Majority of the patients (52.8%) had associated bacterial infections. Discussion and conclusion: The associated risk factors increase the colonisation of this genus by breaking mucosal barrier, later leading to establishment of infection.

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