HIGH LEVEL OF OCCULT HEPATITIS B VIRUS INFECTION IN TREATMENT-NAIVE HIV INFECTED PATIENTS IN COTONOU, BENIN

AFFOLABI DISSOU¹*, SOGBO FREDERIC², KPOSSOU RAIMI³, METODAKOU DESIREE⁴, LAFIA BARNABE⁵, OREKAN JEANNE⁶, MASSOU FARIDATH⁷, KEHINDE ADEREMI⁸, ZANNOU MARCEL^9
1Department of Faculty of Health Sciences, Abomey-Calavi University, Cotonou, Benin; National Teaching Hospital Hubert KoutoukouMaga, Cotonou, Benin
²Department of Faculty of Health Sciences, Abomey-Calavi University, Cotonou, Benin; National Teaching Hospital Hubert KoutoukouMaga, Cotonou, Benin
³Department of Faculty of Health Sciences, Abomey-Calavi University, Cotonou, Benin; National Teaching Hospital Hubert KoutoukouMaga, Cotonou, Benin
⁴National Teaching Hospital Hubert KoutoukouMaga, Cotonou, Benin
⁵National Teaching Hospital Hubert KoutoukouMaga, Cotonou, Benin
⁶Department of Faculty of Health Sciences, Abomey-Calavi University, Cotonou, Benin; National Teaching Hospital Hubert KoutoukouMaga, Cotonou, Benin
⁷Department of Faculty of Health Sciences, Abomey-Calavi University, Cotonou, Benin
⁸Department of Medical Microbiology & Parasitology, College of Medicine, University of Ibadan, Nigeria
⁹Department of Faculty of Health Sciences, Abomey-Calavi University, Cotonou, Benin; National Teaching Hospital Hubert KoutoukouMaga, Cotonou, Benin
* Corresponding Author : affolabi_dissou@yahoo.fr

Received : 24-05-2017     Accepted : 10-06-2017     Published : 28-06-2017
Volume : 9     Issue : 6       Pages : 902 - 904
Int J Microbiol Res 9.6 (2017):902-904

Keywords : HBV, HIV, Occult hepatitis, Benin
Academic Editor : Dr Ranjana Hawaldar
Conflict of Interest : None declared
Acknowledgements/Funding : Authors are thankful to the National AIDS Programme of Benin and The National Reference Laboratory for Mycobacteria, Cotonou, Benin
Author Contribution : Affolabi Dissou: Conception and design of the study, analysis and interpretation of data, drafting the paper, revising the paper

Human Immunodeficiency Virus (HIV) and Hepatitis B virus (HBV) infections share the same routes of transmission and are both endemic in sub-Saharan Africa. Proper management of these infections require reliable diagnosis of co-infected patients. We aimed to assess the magnitude of HBV infection in treatment-naïve HIV infected patients in Cotonou. This cross-sectional study was conducted from July 2014 to January 2015 on consecutively recruited treatment-naïve HIV infected patients attending the National Reference Center for Research and Management of HIV infection. Blood was collected from each patient for detecting HBs antigen (HBs Ag) by ELISA, HIV viral load, HBV viral load and CD4 counts. In total, 133 patients were included with a mean age of 38.3 years and a male to female ratio of 1.0:2.0. HBs Ag was positive in 15 (11.3%) of the patients while HBV viral load was detected in 52 (39.1%). The rate of occult hepatitis B (OBI) e.g. negative HBs Ag but positive HBV viral load was 27.8%. Patients with OBI were more likely to have low HBV viral load (p < 0.001) than those without OBI. In conclusion, the prevalence of OBI is high among treatment-naïve HIV infected patients in Cotonou. Universal access to molecular tests is needed in the country to detect HBV infection in these patients.

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