GSTM1 GENE POLYMORPHISMS AND RISK OF BREAST CANCER IN J&K STATE

RAVI SHARMA¹, JYOTDEEP KOUR RAINA², TARIQ AZAD³, PARVINDER KUMAR⁴, RAKESH KUMAR PANJALIYA⁵*
¹Human Genetics Research Cum Counselling Centre, University of Jammu, Jammu, Jammu and Kashmir, 180006, India
²Human Genetics Research Cum Counselling Centre, University of Jammu, Jammu, Jammu and Kashmir, 180006, India
³Department of Surgery, Govt. Medical College Jammu, Jammu, Jammu and Kashmir, 180006, India
⁴Human Genetics Research Cum Counselling Centre, University of Jammu, Jammu, Jammu and Kashmir, 180006, India
⁵Human Genetics Research Cum Counselling Centre, University of Jammu, Jammu, Jammu and Kashmir, 180006, India; Department of Zoology, University of Jammu, Jammu, Jammu and Kashmir, 180006, India
* Corresponding Author : rakesh_chinab@yahoo.co.in

Received : 27-12-2016     Accepted : 16-04-2017     Published : 28-04-2017
Volume : 9     Issue : 4       Pages : 263 - 265
Genetics 9.4 (2017):263-265

Keywords : GSTM1, null, breast cancer, Jammu
Conflict of Interest : None declared
Acknowledgements/Funding : The authors are thankful to the Science and Engineering Research Board, DST, New Delhi for financial support
Author Contribution : Ravi Sharma and Jyotdeep Kour: Blood sampling and laboratory work

Homozygous deletion of GSTM1 gene affects carcinogenic detoxification and promotes tumorogenesis in breast tissue. The present study was aimed to evaluate the frequency of GSTM1 genotypes/alleles and its association in risk of breast cancer in North Indian population of Jammu (Jammu and Kashmir). A total of 60 confirmed breast cancer patients and 90 healthy unrelated controls were enrolled in this study. Genotyping analysis was performed by Polymerase Chain Reaction (PCR) based methods and odds ratios (ORs) were calculated to know the strength of association. The frequencies of null and positive GSTM1 alleles/genotypes were 0.12/11.67% and 0.88/88.33% in patients whereas in controls it was 0.18/17.78% and 0.82/82.22% respectively. We did not found the association of GSTM1 null genotype towards risk of breast cancer [OR=0.61, 95% CI (0.23-1.59), p=0.6]. The present study is in support of lack of association of null GSTM1 genotype and risk of breast cancer in population of Jammu.

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