OXIDATIVE STRESS RESPONSIBLE FOR GENOTOXIC EFFECTS IN TYPE 2 DIABETES MELLITUS PATIENTS IN POPULATION OF WEST BENGAL

PRIYANKA BISWAS¹*, PRASANTA BHATTACHARYA², MADHUSNATA DE^3
1Department of Genetics, Vivekananda Institute of Medical Science, Ramakrishna Mission Seva Pratishthan, 99 Sarat Bose Road, Kolkata, 700026, West Bengal
²Department of Surgery, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, 99 Sarat Bose Road, Kolkata, 700026, West Bengal
³Department of Genetics, Vivekananda Institute of Medical Science, Ramakrishna Mission Seva Pratishthan, 99 Sarat Bose Road, Kolkata, 700026, West Bengal
* Corresponding Author : priyan_bsws@yahoo.com

Received : 19-06-2016     Accepted : 04-08-2016     Published : 14-08-2016
Volume : 8     Issue : 4       Pages : 201 - 203
Genetics 8.4 (2016):201-203

Keywords : Oxidative stress, Chromosomal aberrations, Oxidative damage, Genomic instability
Academic Editor : Dr Sudipta Chakraborti, Dr Anumoy Mukherjee
Conflict of Interest : None declared
Acknowledgements/Funding : Funding: DST, West Bengal; Acknowledgements: I would like to acknowledge our Secretary, Ramakrishna Mission Seva Pratishthan, DST, West Bengal, senior colleague of our department and all the patients who participated in this study. This study was approved by the institutional ethical committee on 10th May, 2016. Reg No. ECR/62/Inst/WB/2013 issued under Rule 122DD of the Drugs & Cosmetics Rules 1945
Author Contribution : None declared

Type 2 Diabetes mellitus (T2DM) is a chronic, debilitating disease affecting a significant proportion of the population and becoming an epidemic worldwide. Increasing evidence in both, experimental and clinical studies suggest oxidative stress (OS) plays a major role in the pathogenesis of both types of diabetes mellitus and its complications. The OS may exhibit chromosomal instability leading to chromosomal aberration frequencies. A case-control study of sixty-two patients with T2DM (n=62) and ten healthy control subjects (n=10) were screened from different areas of West Bengal. All procedures were done with the informed consent of participants. Blood cultures were done for analyzing chromosome aberrations as per routine procedures In the present study, increased chromosomal aberration frequencies and mitotic index were observed in T2DM patients that may be due to increased oxidative stress leading to different mechanisms like oxidative damage, repair mechanisms and resulting in genomic instability, which in turn may contribute to an increased risk for cancer. Therefore, this study will explore the role of oxidative stress for genomic instability and causing cancer.