Analysis of the genetic diversity of arthritis patients with reference to the factors inducing its onset

Mujapara A.K¹*, Bushra Jarullah²*
¹Disha Life Sciences Pvt. Ltd, 301, Trade center, Gurukul road, Ahemedabad
²Disha Life Sciences Pvt. Ltd, 301, Trade center, Gurukul road, Ahemedabad
* Corresponding Author : dishalifesciences@gmail.com

Received : -     Accepted : -     Published : 21-12-2009
Volume : 1     Issue : 2       Pages : 6 - 9
Genetics 1.2 (2009):6-9
DOI : http://dx.doi.org/10.9735/0975-2862.1.2.6-9

Keywords : RAPD, Arthritis, Seronegative
Conflict of Interest : None declared

A lot of research on the prevalence of arthritis in India population has been carried out. However no studies on the genetic relationships within groups of arthritic patients in India have been reported. The current study focuses on analyzing the genetic diversity between patients suffering from the various types of arthritis with reference to factors inducing its onset. A total of 36 patients suffering from different types of arthritis were analyzed with reference to the age, gender, BMI, family history, hemoglobin and thyroid profile. The variation in the genetic profile was also analyzed using the RAPD technique. Data analysis showed patients suffering from arthritis to be at a greater risk of thyroid disorders, however the type of arthritis played a significant role. A distinct correlation between the genetic variation and presence of arthritis including its type was observed.

[1] Alan J Silman, Jacualine E Person (2002) Arthritis Res, 4(3), S265-S272.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[2] Malaviya A.N., et al., (1993) RheumatolInt, 13,131-134.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[3] David Bjerklie, Time Asia Magazine, 2002  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[4] Remmers, K. Gregersen (2002) The New England Journal of Medicine 6,132-135  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[5] Edward D Harris et al., Coronary artery disease in rheumatoid arthritis: Epidemiology, pathogenesis, and risk factors (2009) 12  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[6] Fre´De´Rique Darbonneau ,Severin Ansart, Rozzan de berre (2003) Arthritis Care & Research, 49(6), 804–809.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[7] Généthon-Safa Saker, UOM-Dorita Galea, SUN-L.Politano, NMTB-C.Angelini Lanchbury J. S. (1998) Molecular immunogenetics 1,21-24  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[8] Tektonidou M. G., Anapliotou M., Vlachoyiannopoulos P., Moutsopoulos H. M. (2004) Ann Rheum Dis 63:1159–1161  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[9] Neil J. Gonter (2008) A.D.A.M., 1-5.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[10] Patwardhan Bhushan (2005) The Journal Of Alternative And Complementary Medicine 11,349–353.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[11] Pavlicek A., Hrda S. and Flegr J. (1999) Folia Biol (Praha), 45(3), 97-99  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[12] Rebeca Dieguez-Gonzalez, Eva Prez Pampin, Jous Lous, Maria Luisa, Fadrico Navaro (2008) BMJ Journals, 1-10.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[13] Rebeca Dieguez-Gonzalez, Eva Prez Pampin, Jous Lous, Maria Luisa, Fadrico Navaro (2008) BMJ Journals, 1-10.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[14] Bailes S.M., Devers J.J., Kirby J.D. and Rhoads D.D. (2007) Poult Sci., 86,102- 106.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[15] Sambrook J., Fritsch E. and Maniatis T. Molecular cloning: A laboratory manual.Second ed. ed. Cold Spring Harbar Laboratory Press, Cold Sping Harbar, New York. (1989)  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[16] Silman and Pearson (2002) Arthritis Res; 4(3),S265  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[17] Sneath P. H. A. and Sokal R. R. Numerical Taxonomy: The Principles and Practice of Numerical Classification. W. H. Freeman, San Francisco, (1973).  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[18] Mishra T.K. (2007) JIACM, 8(4), 324-30  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[19] Thomas Blankenstein, Hans-Dieter Volk', Christine Techert-Jendrusch (1989) Nucleic Acids Research 17:21.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[20] World health organization statistics, WHO stat – (2007) : 8-12  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus