Flaviviridae is the family of viruses and has been studied for many decades. New analytical approaches i.e., Isolation, sequencing, structure elucidation also have been performed. Areas that need to be focused is drugs designing, many of the work have been done for it, but targets remains the non structural proteins, viral binding site still needs to be focused on. Development of new transgenic cell lines, so that it becomes resistant to infection from virus and inturn reduce flaviviral infection can also be potential site to work. Analytical methods to target the virus need to be developed, which could be use to find potential target site to inhibit viral replication.