Increase expenditures on drugs consumptions irrational production, prescription & use of drugs, and potential hazards to patients has been a concern of health professionals and health administrators. The present study was conducted to evaluate the pattern of prescription and use of drugs in the outpatients so as to structure a drug prescription protocol by the department of ophthalmology so as to adopt the system of rational use of drugs. The 766 prescriptions of (952 total drugs ) post-operative patients were analyzed for average number of drugs per prescription, the duration of treatment, the dosage form, the frequency of administration and the percentage of drugs prescribed by their generic names. Prescription analysis showed that the average number of drugs per prescription was 1.22%. The maximum numbers of drugs prescribed were eye drops (48.10 %), followed by ointments (25.31%), tablets (12.81%), capsules (7.98 %), and injections (5.76%). Most of the prescription for one drug demonstrated mention of frequency of drug administration & the duration of treatment. Poor prescribing practice were seen with prescription containing more than two or three drugs. The study reveals minimum common prescription writing errors. However, more than 90% prescriptions were prescribed in by the generic names, suggest a little more improvement in prescription practice and a periodic audit of drug prescription is warranted.