Butea frondosa plant was used in traditional medicine for the treatment of night blindness, dysentery, piles, ulcers, tumors, menustrual disorders, cough, stromatitis, leprocy in early stages, skin diseases etc. Based on the traditional Knowledge about the plant, present study was conducted. To evaluate the scientific basis for the use of plant, the antimicrobial activities of the extracts at different doses (10mg and 20mg/ml) of the leaves were evaluated against some common pathogenic bacteria and fungi using agar disc diffusion method. Gram positive bacteria like staphylococcus aureus, gram negative bacteria like Pseudomonas aeruginosa, Klebsiella Pneumoniae, Escherichia coli, Proteus mirabilis, Proteus vulgaris and fungi like Aspergillus niger, Aspergillus flavus were used and antimicrobial activity of the concentrated extracts was evaluated by the diameter zone of inhibition against the above microorganisms. Plant extracts were active against both gram positive, gram negative Bacteria and fungi. The above observation indicates that, Butea frondosa has broad spectrum antibacterial and antifungal activity and a potential source of new classes of antibiotics that could be useful for infectious disease chemotherapy and control. The study also conducted on the isolation of the chemical constituents present in the plant. The Phytochemical constituents of the dried powdered plant leaves were extracted using aqueous and organic solvents, Results revealed the presence of carbohydrates, Glycosides, Alkaloids ,steroids, Tannins, Phenols.

Different extracts of Butea frondosa was assayed for Anti-ulcer activity in Experimental albino mice. Gastric ulcers were induced using 0.6M Hcl and the induced ulcers treated after half an hour, using oral doses of (250 and 500mg/kg) the extract. The extracts reduced ulcers moderately for the mice receiving 250 and 500mg/kg body wt of the extract. The dose of Chloroform extract (250mg/kg) showed a high reduction of ulceration with a corresponding healing rate of 46.08%.No apparent toxicity signs were observed through food, fluid intakes, animal behavior and stool texture. The above results indicates that different solvent (petroleum ether, chloroform, Ethanol and aqueous) extracts of Butea frondosa leaves posses potent chemical components for the healing of Gastric ulcers.