In Indian population highest numbers of patients are suffering from Coronary heart disease (CHD). It is projected to be 40 million Indians may suffer due to Coronary heart disease by the year 2020 [1]. Present study revealed that conventional markers for CHD are in-sufficient to predict the risk. The measurement of hs-CRP level & clinical indication may predict as a diagnostic marker for early detection of Coronary heart disease. The present study was carried at Padamashree Dr D Y Patil Hospital & Research Centre, Navi Mumbai. Fasting blood samples were collected from male and female patients attending Cardiology & Diabetic Clinics. The study designed between the different groups as diabetic, diabetic with hypertension and Myocardial Infraction & normal healthy individuals between the ages 25-60 years. It was concluded that hs-CRP level was increased significantly in diabetic, diabetic with hypertension and MI, though their lipid levels were within normal range.

Prostacyclin, a potent vasodilator having anti-platelet aggregating properties, is known to play a role in regulating vascular tone and vasoconstrictor response to Angiotensin. In the present study plasma level of 6-keto prostaglandin F as indicator of Prostacyclin activity (PGI2) and Angiotensin I as an indicator of plasma Renin Activity (PRA) in normal pregnant women and pre-eclamptic women were measured using radioimmunoassay. Prostacyclin production was significantly decreased in pre eclampsia compared with normal pregnant women. The results were analyze to establish co-relation with severity of disease and observed a strong negative correlation (r= - 56) between PGI2 & severity of disease, suggesting involvement of this Vasoactive prostaglandin in causation and the associated hypertension of this disorder.