ISSN : 0975-5276
EISSN : 0975-9174
S. PALCHOUDHURI1, ROY D. SINHA2, S. DEBNATH3, M. MOOKERJEE4, S.G. DASTIDAR5*
1Department of Microbiology, Herbicure Healthcare Bio-Herbal Research Foundation, Saral Dighi (E), Boral, Kolkata, 700154, India
2Department of Microbiology, Herbicure Healthcare Bio-Herbal Research Foundation, Saral Dighi (E), Boral, Kolkata, 700154, India
3Department of Botany, Sree Chaitanya College, Habra, North 24 Parganas, West Bengal, India
4Department of Microbiology, NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata 700063, India
5Department of Microbiology, Herbicure Healthcare Bio-Herbal Research Foundation, Saral Dighi (E), Boral, Kolkata, 700154, India
* Corresponding Author : jumicrobiol@yahoo.co.in
Received : 04-11-2019 Accepted : 26-12-2019 Published : 30-12-2019
Volume : 11 Issue : 12 Pages : 1760 - 1763
Int J Microbiol Res 11.12 (2019):1760-1763
Keywords : Mianserin, Phenothiazines, Tetracyclic Compound, Non-Antibiotic, Antidepressant
Academic Editor : Amita Shobha Rao, Dr Dibyajyoti Talukda, Dr Anusha N
Conflict of Interest : None declared
Acknowledgements/Funding : Authors are thankful to Department of Microbiology, Herbicure Healthcare Bio-Herbal Research Foundation, Saral Dighi (E), Boral, Kolkata, 700154, India
Author Contribution : All authors equally contributed
Several different chemotherapeutic agents have been found to possess potent antimicrobial action. The most active compounds were found to be the phenothiazines and also those that are structurally related to phenothiazines. The antidepressant drug mianserin being structurally closely related to phenothiazines was selected to determine its antimicrobial properties. Mianserin was found to exhibit a definite antimicrobial property against 166 strains of bacteria. The minimum inhibitory concentration (MIC) determined with the help of standard agar diffusion technique, ranged from 5-25 µg/ml in most of the strains; however, some were also inhibited even at lower concentrations. Mianserin was found to be bacteriostatic against Staphylococcus aureus as well as Vibrio cholerae. Additionally, the drug exhibited significant protection (P < 0.001) in animal experiments against virulent pathogen Salmonella enterica serovar Typhimurium. Through this detailed investigation it can be inferred that mianserin has remarkable possibilities of combating multidrug resistant infections.
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