SEROLOGICAL STUDY FOR RUBELLA VIRUS INFECTION IN WOMEN WITH BAD OBSTETRIC HISTORY

KASTURI¹*, V.S. RATHOD², S.R. MORE³, S.S. RAUT^4
1Department of Microbiology, Government Medical College, Akola, 444001, Maharashtra University of Health Sciences, Nashik, 422004, Maharashtra, India
²Department of Microbiology, Dr S C Govt. Medical College, Nanded, 431601, Maharashtra University of Health Sciences, Nashik, 422004, Maharashtra, India
³Professor & Head, Department of Microbiology, Dr S C Govt. Medical College, Nanded, 431601, Maharashtra University of Health Sciences, Nashik, 422004, India
⁴Professor & Head, Department of Microbiology, Indira Govt. Medical College, Nagpur, 440008, Maharashtra University of Health Sciences, Nashik, 422004, India
* Corresponding Author : kasturi07081@gmail.com

Received : 01-03-2019     Accepted : 17-03-2019     Published : 30-03-2019
Volume : 11     Issue : 3       Pages : 1506 - 1508
Int J Microbiol Res 11.3 (2019):1506-1508

Keywords : Rubella, congenital rubella syndrome (CRS), Bad obstetric history(BOH), Immunoglobulin G (IgG), Immunoglobulin M (IgM), ELISA
Academic Editor : Dr Shuvankar Mukhophadhaya, Dr Pooja Shah
Conflict of Interest : None declared
Acknowledgements/Funding : Authors are thankful to Dr S C Govt. Medical College, Nanded, 431601, Maharashtra University of Health Sciences, Nashik, 422004, Maharashtra, India
Author Contribution : All authors equally contributed

Rubella virus when contracted during pregnancy results in miscarriage, stillbirth or congenital rubella syndrome (CRS), characterized by deafness, heart disease and cataract. In the present study, blood samples were obtained from 200 antenatal women aged 19-35 years with Bad obstetric history. Sera was separated and tested using ELISA kits provided by Ratio Diagnostics, Frankfurt, Germany.32 and 92 samples were positive for Rubella IgM and IgG antibodies respectively. Only 8 cases were positive for both Rubella IgM and IgG. Rubella seropositivity was highest amongst women who had history of abortion (41.94%) followed by intrauterine death (22.58%). Maximum number of cases (58.06%) belonged to 25-30 years age group, 40.32%cases were in 19-24 years age group. Majority of cases (60.48%) belonged to rural areas. 45.16% seropositive women were housewives, 27.42% were farmers, 19.35% women were labourers. 37.09% cases had education till primary or middle school level and 34.67% cases were illiterate. Thus, we concluded that women of this geographical area may be contracting Rubella infection due to poor hygienic conditions, low level of education, staying indoors which implied poor living conditions.

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