PREVALENCE OF METHICILLIN RESISTANT AND INDUCIBLE CLINDAMYCIN RESISTANT STAPHYLOCOCCAL ISOLATES IN A TERTIARY CARE HOSPITAL

T.C. RUBEE¹, T.S. SUMEETA²*, K.S. PRANAY³, P.I. DIVYA⁴, A.N. GHOSH^5
1Department of Microbiology, Gujarat Adani Institute of Medical Sciences, Krantiguru Shyamji Krishna Verma Kachchh University, Bhuj, Gujarat, 370001, India
²Department of Microbiology, B. J. Medical College, Gujarat University, Ahmedabad, Gujarat 380016, India
³Department of Microbiology, B. J. Medical College, Gujarat University, Ahmedabad, Gujarat 380016, India
⁴Department of Microbiology, B. J. Medical College, Gujarat University, Ahmedabad, Gujarat 380016, India
⁵Department of Microbiology, Gujarat Adani Institute of Medical Sciences, Krantiguru Shyamji Krishna Verma Kachchh University, Bhuj, Gujarat, 370001, India
* Corresponding Author : drsumeetasoni@gmail.com

Received : 10-01-2019     Accepted : 27-01-2019     Published : 30-01-2019
Volume : 11     Issue : 1       Pages : 1455 - 1457
Int J Microbiol Res 11.1 (2019):1455-1457

Keywords : Methicillin Resistant, MLSBc, MLSBi, Staphylococcus., Phenotype
Conflict of Interest : None declared
Acknowledgements/Funding : Authors are thankful to Gujarat Adani Institute of Medical Sciences, Krantiguru Shyamji Krishna Verma Kachchh University, Bhuj, Gujarat, 370001, India. Authors are also thankful to Department of Microbiology, B. J. Medical College, Gujarat University, Ahmedabad, Gujarat 380016, India
Author Contribution : All authors equally contributed

Background: Staphylococcal infections, especially the infections caused by Methicillin Resistant Strains have become a big concern due to its increasing resistance to several other antibiotics. Macrolide–lincosamide streptogramin B (MLSB) antibiotics are used as an alternative to vancomycin to treat such infections. However, widespread use of these antibiotics has also led large no. of staphylococcus strains resistant to them. Methods: This study was conducted for a period of a year from January 2017 to December 2017. Phenotypic detection of Methicillin resistance Staphylococcal isolates was detected by cefoxitin disc diffusion method and Inducible Clindamycin resistant was detected by erythromycin and clindamycin disc approximation test (D-test). Results: Among the 217 clinical isolates of Staphylococcus spp. 90(41.4%) were found to be Methicillin resistant, 28(21.8%) were inducible MLSB phenotype (MLSBi), 78(60.9%) were constitutive MLSB phenotype (MLSBc) and 22(17%) were Macrolide Streptogramin (MS) phenotype. Conclusion: It emphasizes the need of D-test to be performed as a routine test while using clindamycin as an alternative choice to anti-Staphylococcal antibiotics in the treatment of Methicillin resistant Staphylococcal infections. There is also a need to monitor the antimicrobial susceptibility pattern and judicious use of antibiotics to reduce the incidence of these infections.

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