5′ UTR OF IGE EPSILON (Ε) HEAVY CHAIN AND ITS ASSOCIATION WITH MIXED NATURAL INFESTATION OF Haemonchus contortus IN ROHILKHANDI GOAT

KUSH SHRIVASTAVA¹, PUSHPENDRA KUMAR²*, MOHD. FAHEEM KHAN³, NIHAR RANJAN SAHOO⁴, OM PRAKASH⁵, AMIT KUMAR⁶, REBEKA SINHA⁷, ANUJ CHAUHAN⁸, MANJIT PANIGRAHI⁹, BHARAT BHUSHAN¹⁰, ARVIND PRASAD¹¹, A. NASIR¹², B.H.M. PATEL^13
1Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India.
²Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India.
³Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India.
⁴Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India.
⁵Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India
⁶Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India
⁷Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India
⁸Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India
⁹Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India
¹⁰Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India
¹¹Division of Parasitology, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India
¹²Division of Parasitology, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India
¹³LPM Section, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh India
* Corresponding Author : pushpendra64@gmail.com

Received : 17-06-2018     Accepted : 27-06-2018     Published : 30-06-2018
Volume : 10     Issue : 6       Pages : 452 - 454
Genetics 10.6 (2018):452-454

Keywords : IgE, 5′ UTR, Haemonchus contortus, Rohilkhandi goat, FEC
Academic Editor : Suleyman Cylek
Conflict of Interest : None declared
Acknowledgements/Funding : Author thankful to the Director, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, Bareilly, Uttar Pradesh, India. Author also thankful to Indian Council of Agricultural Research, New Delhi for providing financial assistance in the form of fellowship
Author Contribution : All author equally contributed

Immunoglobulin E has a prominent role in allergic reactions specially those launched against parasites. It has been thought that IgE dependent immune response has been evolved to target specifically metazoan parasites that are too large for phagocytosis. In the current manuscript, we explored the possibility of association between polymorphism at 5′ UTR of IgE gene and faecal egg count in case of natural exposure to Haemonchus contortus in Rohilkhandi goat breed. We studied the polymorphism by means of direct sequencing and made four haplotypes. Among these, the haplotype B was having significantly highest FEC value (575.00 ± 450.00 epg) at P< 0.05.

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