ANTIMICROBIAL RESISTANCE OF Salmonella enterica serovars typhi and paratyphi FROM BLOOD ISOLATES IN CHILDREN FROM A NORTH DELHI TERTIARY CARE HOSPITAL

S. JAIN¹, N. SHREE²*, M. SHARMA³, S. SATIJA⁴, M. KUMAR^5
1Department of Microbiology, Hindu Rao Hospital, Malka Ganj, New Delhi, Delhi 110007
²Department of Microbiology, Hindu Rao Hospital, Malka Ganj, New Delhi, Delhi 110007
³Department of Microbiology, Hindu Rao Hospital, Malka Ganj, New Delhi, Delhi 110007
⁴Department of Microbiology, Hindu Rao Hospital, Malka Ganj, New Delhi, Delhi 110007
⁵Department of Microbiology, Hindu Rao Hospital, Malka Ganj, New Delhi, Delhi 110007
* Corresponding Author : drneetushree@gmail.com

Received : 12-02-2018     Accepted : 06-04-2018     Published : 30-04-2018
Volume : 10     Issue : 4       Pages : 1123 - 1125
Int J Microbiol Res 10.4 (2018):1123-1125
DOI : http://dx.doi.org/10.9735/0975-5276.10.4.1123-1125

Keywords : Multidrug resistance (MDR), nalidixic acid resistant Salmonella typhi (NARST), enteric fever
Conflict of Interest : None declared
Acknowledgements/Funding : Author thankful to Department of Microbiology, Hindu Rao Hospital, Malka Ganj, New Delhi, Delhi 110007.
Author Contribution : All authors equally contributed

Background: Salmonella typhi and paratyphi are mainly responsible for causing enteric fever in India. Widespread use of some common antimicrobial agents led to emergence of Salmonella strains with reduced susceptibility and multidrug resistance. Susceptibility pattern keep changing and vary from place to place with time. Methods: A retrospective study was carried out to evaluate Salmonella blood isolates in children < 15 years, in relation to specific serotype, age distribution and prevalent antimicrobial resistance pattern. Results: Salmonella typhi was most common serotype isolated, accounting for 89.2% of total isolates. None of Salmonella isolates were MDR and all were resistant to nalidixic acid. Ciprofloxacin resistance was found in 34.2% of isolates. Low level resistance was seen towards first line antimicrobials including ampicillin (7.2%), chloramphenicol (5.4%) and cotrimoxazole (2.7%). Conclusion: Emergence of antimicrobial resistance in typhoidal Salmonellae constitutes a new challenge. Re-emergence of strains sensitive towards first line antimicrobial agents emphasizes concept of antibiotic recycling in hospitals.

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