CATHETER RELATED BLOODSTREAM INFECTIONS (CRBSI) IN INTENSIVE CARE UNITS: A PROSPECTIVE STUDY OF ITS RATE, MICROBIOLOGICAL PROFILE AND ASSOCIATED FACTORS

V. MALLIKARJUN RAO¹*
¹Department of Microbiology, Shadan Institute of Medical Sciences and Research Centre, Hyderabad, 500008, Telangana, India
* Corresponding Author : vishwanathrao56@gmail.com

Received : 23-03-2018     Accepted : 06-04-2018     Published : 30-04-2018
Volume : 10     Issue : 4       Pages : 1117 - 1119
Int J Microbiol Res 10.4 (2018):1117-1119
DOI : http://dx.doi.org/10.9735/0975-5276.10.4.1117-1119

Keywords : catheter related bloodstream infections (CRBSI), antibiotic susceptibility microbiological profile, Staphylococcus aureus
Conflict of Interest : None declared
Acknowledgements/Funding : Author thankful to Dr NTR University of Health Sciences, Gunadala, Vijayawada, Andhra Pradesh 520008
Author Contribution : Sole Author

Background: Central venous catheters (CVC) are integral to the modern intensive care practices and its inevitable use also makes patients prone to Catheter-related bloodstream infection (CRBSI). The aim of the present study was to prospectively study the rate; microbiological profile with antibiotic susceptibility and associated factors of central venous catheter related bloodstream infections (CRBSI) in intensive care units of a tertiary hospital in South India. Materials and Methods: The present study was a case control study conducted on 109 patients with CVC in situ. Quantitative blood cultures (QBC) and catheter tip cultures were performed; microbiological profile and antimicrobial susceptibility were assessed. Results: CRBSI was diagnosed in (18/109) patients and the rate of CVC- Blood stream infection number of CVC days was calculated as 13.64 per 1000 catheter days. The mean age of cases was observed to be 51.25(+-6.98) yrs. Patients from surgical ICU; signs of inflammation around catheter site, length of ICU stay, having underlying co-morbid conditions were significantly associated with CRBSI. Staphylococcus aureus followed by Pseudomonas aeruginosa and non-albicans Candida were common CRBSI pathogens and the bacterial agents were found to be multidrug-resistant (MDR). Conclusion: The incidence of CRBSI was 16.52% and the rate was 13.64 per 1000 catheter day. CRBSI were significantly associated with higher mean age; longer duration of catheterisation and longer stay in ICU.

1. Gahlot R., Nigam C., Kumar V., Yadav G. and Anupurba S. (2014) International Journal of Critical Illness and Injury Science, 2014; 4(2),162-167.
2. Pawar M., Mehta Y., Kapoor P., Sharma J., Gupta A. and Trehan N. (2004) J CardiothoracVascAnesth, 18, 304-8.
3. Mehta A., Rosenthal V.D., Mehta Y., Chakravarthy M., Todi S.K., Sen N., et al. (2007) J Hosp Infect., 67,168-74.
4. Chopdekar K., Chande C., Chavan S., Veer P., Wabale V., Vishwakarma K., et al. (2011) Indian J Med Microbiol., 29,169-71.
5. Kaur M., Gupta V., Gombar S., Chander J., Sahoo T. (2015)Indian J Med Microbiol 2015;33:248-54.
6. Tang H.J., Lin H.L., Lin Y.H., Leung P.O., Chuang Y.C., Lai C.C. (2014) BMC Infect Dis., 14(1), 356–356.
7. Singh S., Pandya Y., Patel R., Paliwal M., Wilson A. and Trivedi S. (2010) IJMM, 28(4), 342–7.
8. Parameswaran R., Sherchan J.B., Varma D.M., Mukhopadhyay C. and Vidyasagar S. (2011) J Infect Dev Ctries., 5, 452–8.
9. Eggimann P. and Pittet D. (2002) ClinMicrobiol Infect, 2002,8,295-309
10. Haddadin Y., Regunath H. Central Line Associated Blood Stream Infections (CLABSI) [Updated 2017 Mar 28]. In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2018.
11. Donlan R.M. (2001) Emerg Infect Dis., 7, 277-81.
12. Raad I., Hanna H. and Maki D. (2007) Lancet Infect Dis., 7, 645-57.
13. CDC(2011) National and State Healthcare Associ ated Infections
14. Patil H.V., Patil V.C., Ramteerthkar M.N. and Kulkarni R.D. (2011) Indian J Crit Care Med., 15, 213-23.
15. Deshpande K.S., Hatem C., Ulrich H.L., Currie B.P., Aldrich T.K., Bryan-Brown C.W., et al. (2005) Crit Care Med., 33, 13-20, discussion 234-5.
16. Yilmaz G., KoksalI., Aydin K., Caylan R., Sucu N., Aksoy F. (2007) J. Parenter. Enter. Nutr., 31, 284–287.
17. Latif S., Anwar M.S., Ahmed I. (2009) Biomed., 25:101-5.
18. Hocquet D., Berthelot P., Roussel-Delvallez M., Favre R., Jeannot K., Bajelot O., et al. (2007) Antimicrob Agents Chemother., 51, 3531-6.