RAZIA KHATOON1, NOOR JAHAN2*
1Department of Microbiology, Hind Institute of Medical Sciences, Mau, Ataria, Sitapur, 261303, India
2Department of Microbiology, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, India
* Corresponding Author : drnoorj@rediffmail.com
Received : 12-01-2018 Accepted : 21-01-2018 Published : 30-01-2018
Volume : 10 Issue : 1 Pages : 1001 - 1004
Int J Microbiol Res 10.1 (2018):1001-1004
DOI : http://dx.doi.org/10.9735/0975-5276.10.1.1001-1004
Keywords : Seroprevalence, Hepatitis C infection, Risk factors, Pregnant women
Academic Editor : Dr Sudipta Chakraborti
Conflict of Interest : None declared
Acknowledgements/Funding : Authors are thankful to Department of Microbiology, Hind Institute of Medical Sciences, Mau, Ataria, Sitapur, 261303 and Integral Institute of Medical Sciences & Research, Integral University, Lucknow-226026, India
Author Contribution : Both authors have equally contributed
Hepatitis C virus (HCV) is a major cause of viral hepatitis and hepatic dysfunction during pregnancy throughout the world. HCV infection leads to complications like premature labour, preterm delivery and maternal mortality. Virus may be transmitted vertically to neonates leading to neonatal hepatitis. The present study was done to estimate the seroprevalence of Hepatitis C virus infection among pregnant women. Total of 2067 pregnant women were enrolled in the study whose serum sample was tested for anti-Hepatitis C virus antibody using rapid test and those found reactive were confirmed using enzyme linked immunosorbent assay (ELISA). Out of 2067 pregnant women tested, 24 were found to be reactive by both rapid test and ELISA, hence the seroprevalence was 1.2%. Maximum seropositivity was seen in pregnant women of age group 26-30 years. Seropositivity was more among working pregnant women, belonging to rural areas and those who were poor and belonged to lower socio-economic class. All these findings were statistically significant. Amongst the risk factors studied, most of the seropositives gave history of previous surgery followed by history of dilatation and curettage. To conclude, it is strongly recommended that all pregnant women should be screened for anti-Hepatitis C virus antibodies in order to know their infection status and thus prevent adverse outcome of pregnancy and its vertical transmission to their neonates.
1. Pyadala N., Maity S.N., Kothapalli J., Goud A.K., Borugadda R., Mallepaddi P.C. and Polavarapu R. (2016) Int J Res Dev Pharm Life Sciences, 5, 2251-4.
2. Kumar A., Sharma K.A., Gupta R.K., Kar P. and Chakravarti A. (2007) Indian J Med Res, 126, 211-5.
3. Karoney M.J. and Siika A.M. (2013) The Pan Afri Med J, 14, 44.
4. Global surveillance and control of hepatitis C (1999) J Viral Hepat, 6, 35-47.
5. Shepard C.W., Finelli L. and Alter M.J. (2005) Lancet Infect Dis, 5, 558-67.
6. Chowdhury A., Santra A., Chaudari S., Dhali G.k., Maity S.G., Naik T.N., Bhattacharya S.K. and Mazumder D.N. (2003) Hepatology, 37, 802-9.
7. ACOG Educational Bulletin. Viral hepatitis in pregnancy. Number 248, July (1998) Int J Gynaecol Obstet, 63,195-202.
8. Chen S.L. and Morgan T.R. (2006) Int J Med Sci, 3, 47.
9. Reddick K., Jhaveri R., Gandhi M., James A. and Swamy G. (2011) J Viral Hepatitis, 18, e394–e398.
10. Safir A., Levy A., Sikuler E. and Sheiner E. (2010) Liver International, 30, 765–70.
11. Sookoian S. (2006) Ann Hepatol, 5, 231–6.
12. Wright T.L. (2006) Am J Gastroenterol, 101, 1–6.
13. Kumar N., Gupta N. and Kishore J. (2012) Indian J Pub Health, 56, 103-4.
14. Ishaq T., Khattaq M.I., Amin S. and Haq N.U. (2011) Frequency and risk factors for hepatitis C among pregnant women. Gomal J Med Sci; 9: 166-9.
15. Garner J.J., Gaughwin M., Dodding J. and Willson K. (1997) Med J Aust, 166, 470-2.
16. Silverman N.S., Jenkin B.K., Wu C., Mcgilennen P. and Knee G. (1993) Am J Obstet Gynecol, 169, 583-7.
17. Bohman V.R., Stettler W., Little B.B., Wendel G.D., Sutor L.J. and Cunningham F.G. (1992) Obstet Gynecol., 80, 609-13.
18. Marranconi F., Fabris P., Stecca C., Zampieri L., Bettini M.C., Di Fabrizio N. and de Lalla F. (1994) Infection, 22, 333-7.
19. Wasley A.D. and Alter M.J. (2000) Semin Liver Dis., 20, 1-16.
20. Stevens C.E., Taylor P.E., Pindyck J., Choo Q.L., Bradley D.W., Kuo G. and Houghton M. (1990) JAMA, 263, 49-53.
21. Dayal S., Singh A., Chaturvedi V., Pathak A., Gupta V. and Jaiswal S. (2015) Ann Clin Chem Lab Med, 1, 3-7.
22. Ahmad I., Khan S.B., Rahman H.U., Khan M.H. and Anwar S. (2006) Gomal J Med Sci, 4, 61–4.
23. Hutin Y., Hauri A. and Armstrong G. (2003) BMJ, 327, 1073-8.