INCIDENCE OF M. mucogenicum INFECTION IN TERTIARY CARE HOSPITAL INDIA: RECENT INCREASE IN NUMBER OF NTM CASES

CHANDA R. VYAWAHARE¹, SAVITA V. JADHAV²*, RABINDRA NATH MISRA³, NAGESWARI R. GANDHAM⁴, SWARUPA HATOLKAR^5
1Department of Microbiology, Dr. D Y Patil Medical College, Pune
²Department of Microbiology, Dr. D Y Patil Medical College, Pune
³Department of Microbiology, Dr. D Y Patil Medical College, Pune
⁴Department of Microbiology, Dr. D Y Patil Medical College, Pune
⁵Department of Microbiology, Dr. D Y Patil Medical College, Pune
* Corresponding Author : patilsv78@gmail.com

Received : 16-08-2017     Accepted : 27-09-2017     Published : 28-10-2017
Volume : 9     Issue : 10       Pages : 959 - 962
Int J Microbiol Res 9.10 (2017):959-962

Keywords : NTM, M. mucogenicum, LiPA
Conflict of Interest : None declared
Acknowledgements/Funding : Author are thankful to Department of Microbiology, Dr. D Y Patil Medical College, Pune
Author Contribution : All author equally contributed

Nontuberculous mycobacteria (NTM) are emerging pathogens that affect both immune-compromised and immune-competent patients. Recently Mycobacterium mucogenicum (M. mucogenicum) has been identified as significant cause of post surgical wound infection, soft tissue infection, catheter related sepsis, peritonitis, following peritoneal dialysis, bacterimia in patients undergoing haemodialysis, and central venous line associated sepsis, meningitis, pneumonia and lymphadenitis. Aims and objectives: The present study was designed for retrospective analysis to identify incidence of M. mucogenicum from various clinical samples and to do comparative analysis with reference to clinical syndrome, predisposing factors and its demographic information. Materials and Methods: Various clinical samples were received from suspected NTM infection with symptomatic and compatible radiographic findings. Isolation, identification of NTM and M. mucogenicum were done by standard conventional methods and liquid culture in automated MB BacT culture system. Molecular genotyping were done by Line probe assay (LiPA) for identification of NTM and M. mucogenicum. Results: A total of 13 strains of M. mucogenicum were identified out of 30 NTM strains. Of the total M. mucogenicum; 11 [85%] of the strains were isolated from extra pulmonary origin and 2 [15%] strains were from lung infections; of which 1 was of the paediatric patient having tuberculous lymphadenitis and 1 case was from geriatric age group having tuberculous appendicitis only one case was immune-compromised while remaining 12 cases were immune-competent. Isolation of M. mucogenicum from case of endometrium and sub ovarian cyst were rare findings from present study. Conclusion: Attention should be given to M. mucogenicum isolates as a possible etiology of infection. Clinicians should be alert to those unique aspects of NTM disease concerning diagnosis with advanced molecular methods and successful treatment with limited options.

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