ISSN : 0975-5276
EISSN : 0975-9174
V. IMAYAKUMARI1, P. KENNEDY KUMAR2*, SENITA SAMUEL3, K.S. SRIDHARAN4
1Department of Medical & Molecular Microbiology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra University, Porur, Chennai, 600118, India
2Department of Microbiology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra University, Porur, Chennai, 600118, India
3Department of Microbiology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra University, Porur, Chennai, 600118, India
4Department of Microbiology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra University, Porur, Chennai, 600118, India
* Corresponding Author : kennychennai1973@gmail.com
Received : 14-06-2017 Accepted : 22-06-2017 Published : 28-07-2017
Volume : 9 Issue : 7 Pages : 905 - 908
Int J Microbiol Res 9.7 (2017):905-908
Keywords : Hypoalbuminaemia, ARDS, Acute kidney injury, ELISA, Undifferentiated febrile illness
Academic Editor : Abhishek M Phatak
Conflict of Interest : None declared
Acknowledgements/Funding : Author thankful to Sri Ramachandra Medical College & Research Institute, Sri Ramachandra University, Porur, Chennai, 600118, India
Author Contribution : All author equally contributed
Introduction: Scrub typhus(ST) being a re-emerging zoonotic Rickettsial disease, presenting as undifferentiated febrile illness and goes under diagnosed due to low suspicion rate. Objective: To study the incidence of Scrub typhus in samples meant for fever panel investigation in a tertiary care center. To compare and correlate the statistical significance of blood biochemical and blood counts. Method: A cross-sectional study was conducted for 6 months. During which 122 samples were screened for scrub typhus using Immunochromatographic test (ICT) and Enzyme Linked Immuno Sorbent Assay (ELISA). Both hematological and biochemical parameters were recorded for all the samples to compare their clinical significance. A detailed clinical history was collected and recorded for 14 Scrub typhus positive patients. Results: Out of 122 samples screened 22 (18%) of them were positive for ST either by ICT or ELISA. Among the 14 ST patients 6(42.9%) of them presented with co morbidities viz., pulmonary tuberculosis 2(14.3%) followed by 1(7.1%) each with Multiple organ dysfunction, Acute Respiratory Distress Syndrome (ARDS), Acute kidney injury (AKI), and Chronic Kidney Disease (CKD). Incidentally 3(21.4%) of the patients had co infections with dengue, hepatitis A and B. Summary and Conclusion: Our study shows ST to be considered as one of the common cause for febrile illness as the incidence was 18 % with male preponderance. Early diagnosis and treatment can bring down the morbidity and mortality. Hypoalbuminemia had a statistical significance (p-value: 0.004) than other parameters. Further studies like molecular assays can give more information.
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