A RETROSPECTIVE STUDY OF HIV/HBV CO-INFECTION AND HIV/HCV CO-INFECTION WITH ITS EFFECT ON DISEASE PROGRESSION AND ITS OUTCOME: AN EXPERIENCE AT TERTIARY CARE ART CENTRE

H.R. SHAH¹, B.D. VAGHANI²*, B.K. AMIN³, B.D. MANKAD⁴, S.N. PATEL⁵, A.D. THAKKAR^6
1Department of Medicine, Gujarat Medical Education & Research Society Medical College, Sola, Ahmedabad - 380 062, Gujarat, India.
²Department of Pathology, B.J. Medical College, Ahmedabad - 380 016, Gujarat, India.
³Department of Medicine, B.J. Medical College, Ahmedabad - 380 016, Gujarat, India.
⁴Department of Medicine, Gujarat Medical Education & Research Society Medical College, Sola, Ahmedabad - 380 062, Gujarat, India.
⁵MBBS, Gujarat, India.
⁶MBBS, Gujarat, India.
* Corresponding Author : binal9913397576@gmail.com

Received : 23-02-2015     Accepted : 31-03-2015     Published : 12-04-2015
Volume : 7     Issue : 1       Pages : 604 - 609
Int J Microbiol Res 7.1 (2015):604-609

Keywords : Seroprevalence, CDC Criteria, S. Billirubin, S. AST
Academic Editor : Dr Sumeeta Soni, Dr Run Zhi Lai
Conflict of Interest : None declared

Introduction: The advent of highly active antiretroviral therapy has brought with it a great sense of optimism for people living with HIV and their clinicians. It has been estimated that approximately one third of deaths of patients with HIV infection are in some way related to liver disease co-infections such as hepatitis B or C. And these continue to present challenges in the overall management of the HIV-infected patient. The prevalence of HIV and viral hepatitis co-infection has considerable geographic and demographic variability. In western world, 9-12% & 9-16% of HIV patients have HBV & HCV co-infection respectively. The literature regarding the prevalence of co-infection with HBV/HCV in India is sparse. Hence the present study was conducted to find out prevalence of HBV/HCV co-infection in HIV patients in Gujarat. Objectives: To study the prevalence, epidemiological and biochemical profile of HIV/ HBV and HIV/ HCV co-infection in PLHA along with study of HBV/HCV as a co-factor in HIV disease progression & vice versa. Materials and Method: Study of 80 HIV/ HBV co infected, 66 HIV/ HCV co infected patients out of 2397 PLHA was conducted who visited to ART Center, Civil Hospital Ahmedabad, over the period of two years. Evaluation of each patient for HIV & HBV/HCV co-infection, medical care & provision of HAART is free of charge to all patients at ARTC, Ahmedabad as per NACO guide lines. Patients were considered to have HBV co-infection when HBsAg could be detected in Plasma & considered to have HCV co-infection when anti HCV was present. PLHA with negative HBsAg and negative anti-HCV were considered HIV monoinfected. Results: In present study total male patients were 66.45% and female patients were 33.08%, which is comparable to GSACS having total, male patients 71.7% and female patients 28.8 % and NACO having male patients 70.7% and female patients 29.3%. It shows males are more affected than females in HIV. Male to female ratio is nearly 2:1. Out of 2397 HIV patients, 166 (6.92%) belonged to age 45 years. Out of 80 HIV/ HBV co-infected patients 64 (80%) patients and out of 66 HIV/ HCV co-infected patients 50 (75.75%) patients belonged to the age group 20-45 years. Conclusion: Out of 2397 PLHA screened in present study total male patient were 66.45% and females patients were 33.08%. It shows males are more affected than females in PLHA. In present study HIV/ HBV co-infection is more prevalent in male than in female (M: F- 7:1). While in HIV/ HCV co-infected patients, prevalence in male is nearly same as in female (M: F-1.2:1). The Seroprevalence of HBV (3.34%) is 1.36 times higher than Seroprevalence of HCV (2.75%) in our population of PLHA (2397).