PREVALENCE OF UROPATHOGENS IN URINARY TRACT INFECTION AND THEIR ANTIMICROBIAL RESISTANCE PATTERN IN A NORTH DELHI HOSPITAL, INDIA: A NINE YEAR STUDY

JAIN S.¹, SHARMA M.², KUMAR M.³, SHREE N.⁴, SHARMA Y.^5
1Department of Microbiology, Hindu Rao and NDMC Medical College, Delhi- 110 007, India.
²Department of Microbiology, Hindu Rao and NDMC Medical College, Delhi- 110 007, India.
³Department of Microbiology, Hindu Rao and NDMC Medical College, Delhi- 110 007, India.
⁴Department of Microbiology, Hindu Rao and NDMC Medical College, Delhi- 110 007, India.
⁵Department of Microbiology, Hindu Rao and NDMC Medical College, Delhi- 110 007, India.

Received : 05-06-2014     Accepted : 03-07-2014     Published : 24-07-2014
Volume : 6     Issue : 1       Pages : 545 - 552
Int J Microbiol Res 6.1 (2014):545-552

Background: Urinary tract infection is one of the most common infections seen in both community and hospital setting in developing countries. Area specific prevalence studies aimed to gain knowledge about the type of pathogens responsible for urinary tract infection and their resistance pattern may help the clinicians to choose the correct empirical treatment. Objective: The aim of the study is to evaluate the prevalence of various uropathogens in suspected UTI patients and to find out their antimicrobial resistance pattern and long term trend. Methods: A hospital based retrospective study conducted at Department of Microbiology, Hindu Rao Hospital, New Delhi. Urine samples, collected using mid stream clean catch method over a period of nine years from clinically suspected UTI patients, from various OPDs and wards of our hospital. The samples were tested for uropathogens using standard microbiological procedures. Antimicrobial susceptibility testing was performed on the bacterial isolates using Kirby-Bauer disk diffusion method as per Clinical and Laboratory standards institute guidelines. Results: Of the 57255 samples evaluated, UTI was found in 15.6% (8921) of patients. E.coli (4838, 54.23%), and Klebsiella spp. (1905 21.35%), were the most common pathogens isolated followed by Staphylococcus spp. (746, 8.4%). A large proportion of uropathogens were resistant to common antimicrobial agents used for empirical treatment of UTI Conclusion: E.coli remained as the most common pathogen causing UTI. Nine years trend shows an increase in antimicrobial resistance levels in uropathogens. Rising level of antimicrobial resistance leaves the clinicians with limited options for empirical treatment of UTI. Periodic surveillance monitoring studies are very important to know the changing pattern of antimicrobial resistance among uropathogens, helping physicians to formulate the most effective empirical treatment of UTIs.

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