MICROSPHERES FOR INTRANASAL DELIVERY SYSTEM: AS REVIEW

KOYANI V.¹, DEDAKIA A.², MATHOLIYA C.³, PATEL P.^4
1Department of Pharmaceutical Science, Saurashtra University, Rajkot- 360 001, Gujrat, India
²Department of Pharmaceutical Science, Saurashtra University, Rajkot- 360 001, Gujrat, India
³Department of Pharmaceutical Science, Saurashtra University, Rajkot- 360 001, Gujrat, India
⁴Department of Pharmaceutical Science, Saurashtra University, Rajkot- 360 001, Gujrat, India

Received : 10-11-2013     Accepted : 15-05-2014     Published : 18-06-2014
Volume : 2     Issue : 1       Pages : 14 - 19
Bioinfo Drug Targets 2.1 (2014):14-19

Intranasal administration is an attractive option for local and systemic delivery of many therapeutic agents. The nasal mucosa is easily accessible compared to other mucous membranes and provides a practical entrance portal for wide range of molecules. Intranasal administration is essentially painless application, provide a rapid onset of action and improve the bioavailability for brain targeted nasal drug delivery. Intranasal administration offers a variety of attractive options for local and systemic delivery of diverse therapeutic agents. The nature of the nasal mucosa provides a series of unique attributes, all of which may cosider for patient’s convenience, compliance safety. Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs is increased. Since the nasal mucosa is consider as a targeted drug delivery and a wide variety of therapeutic compounds may be administered intranasaly for topical, systemic and central nervous system action. In this study, a novel mucoadhesive microsphere for nasal administration was developed and investigated. The drug loaded mucoadhesive microspheres were prepared by many technique that can be proposed as an alternative to the conventional methods for preparation of microspheres. It was found that the particle size, swelling index and entrapment efficiency of microspheres increases with increasing drug to polymer ratio. Microspheres show adequate adhesion to nasal mucosa and do not have any destructive effect on nasal mucosa.