EXPLORATION OF SCHIZOPHRENIA: A NEUROLOGICAL DISORDER USING BIOINFORMATICS TOOLS AND TECHNIQUES

Bajaj N.J.¹, Chitlange N.R.², Shaikh Ubed³, Sanjaykumar Chaubey⁴, Gomase V.S.^5
1School of Technology, SRTM University, Sub-Centre, Latur, 413531, MS, India
²School of Technology, SRTM University, Sub-Centre, Latur, 413531, MS, India
³School of Technology, SRTM University, Sub-Centre, Latur, 413531, MS, India
⁴School of Technology, SRTM University, Sub-Centre, Latur, 413531, MS, India
⁵School of Technology, SRTM University, Sub-Centre, Latur, 413531, MS, India

Received : -     Accepted : -     Published : 15-06-2010
Volume : 1     Issue : 1       Pages : 1 - 3
Int J Comput Biol 1.1 (2010):1-3

Keywords : Schizophrenia, genetic factor, ligand, COMT, Drug design
Conflict of Interest : None declared

Schizophrenia is one of the most confusing and disabling mental illness that makes it difficult to tell the difference between real and unreal experiences, to think logically, to have normal emotional responses, and to behave normally in social situations. Schizophrenia may occur due to environmental as well as the genetic factor. COMT is one of the genes responsible for Schizophrenia. We predicted the active site of COMT gene and its complementary ligand structures. This complementary ligand binds to the active site of the gene COMT. Binding ability of ligand to the COMT is important in drug design for curing Schizophrenia.

[1] Schizophrenia" Concise Medical Dictionary. Oxford University Press, 2010. Oxford Reference Online. Oxford University Press. Maastricht University Library. 29 June 2010  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[2] Castle D., Wessely S., Der G., Murray R.M. (1991) The British Journal of Psychiatry 159: 790–4.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[3] Grossman M.H., Emanuel B.S., Budarf M.L. (1992) Genomics 12 (4): s = 822–5.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[4] Chothia C. and Lesk A.M. (1986) EMBO J, 5:823-6  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[5] Bachmair A., Finley D. and Varshavsky A. (1986) Science 234, 179-186  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[6] Gonda D.K., Bachmair A., Wunning I., Tobias J.W., Lane W.S. and Varshavsky A. J. (1989) J. Biol. Chem. 264, 16700-16712  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[7] Garnier J., Gibrat J.F., Robson B. (1996) Methods in Enzymology 1996 R.F. Doolittle Ed., vol 266, 540-553.  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[8] Lupas A., Van Dyke M., Stock J. (1991) Science, 252(5010):1162- 1164  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[9] Rost B., Casadio R., Fariselli P., Sander C. (1995) Protein Sci., 4(3):521-33  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[10] Macindoe G., Mavridis L., Venkatraman V., Devignes M.-D., Ritchie D.W. (2010) Nucleic Acids Research, 38, W445-W449  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus  

[11] Guex N. and Peitsch M.C. (1997) Electrophoresis 18, 2714-2723  
» CrossRef   » Google Scholar   » PubMed   » DOAJ   » CAS   » Scopus