Sanjay Kumar Choubey1, Prashant Srivastava2, Saurabh Shukla3, Gomase V.S.4
1Yeshwant College of Information Technology (Bioinformatics & Biotechnology), Parbhani, MS
2Yeshwant College of Information Technology (Bioinformatics & Biotechnology), Parbhani, MS
3Yeshwant College of Information Technology (Bioinformatics & Biotechnology), Parbhani, MS
4School of Technology, S.R.T.M. University, Sub-Centre, Latur, 413512, India
Received : - Accepted : - Published : 15-06-2010
Volume : 1 Issue : 1 Pages : 1 - 9
J Biotechnol Lett 1.1 (2010):1-9
DOI : http://dx.doi.org/10.9735/0976-7045.1.1.1-9
Conflict of Interest : None declared
There are specific alterations in the structure or function of ion channels in the epileptic brain. Few of the alterations may trigger hyperexcitability and the others prevent nerve cells from being damaged due to epileptic discharges. Ion channels assist in regulation of the excitation in the CNS. Mutation in ion channel genes contributes to epileptic seizures. AnkyrinG, a family of adaptor proteins helps in association of integral membrane proteins to the spectrin-actin based membrane skeleton. Abscence of AnkyrinG expression may lead to impaired ability in generating action potential. Sodium ion channel requires AnkyrinG for its proper localization. In absence of AnkyrinG clustering of voltage gated sodium channel is affected which is required for generating action potential.
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