PREVALENCE AND ANTIBIOGRAM OF KLEBSIELLA SPECIES RECOVERED FROM CLINICAL SAMPLES AT THE KOMFO ANOKYE TEACHING HOSPITAL IN GHANA

Feglo P.K.¹, Acheampong D.O.², Gbedema S.Y.³*
¹Department of Clinical Microbiology, School of Medical Sciences, College of Health Sciences, KNUST, Kumasi, Ghana
²Department of Clinical Microbiology, School of Medical Sciences, College of Health Sciences, KNUST, Kumasi, Ghana
³Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, KNUST, Kumasi, Ghana
* Corresponding Author : sgbedema.pharm@knust.edu.gh

Received : -     Accepted : -     Published : 21-12-2010
Volume : 1     Issue : 2       Pages : 4 - 8
J Clin Res Lett 1.2 (2010):4-8
DOI : http://dx.doi.org/10.9735/0976-7061.1.2.4-8

Keywords : Klebsiella species, antibiotic resistance, aminoglycosides, cephalosporins
Conflict of Interest : None declared
Acknowledgements/Funding : We are grateful to Mr R. Lartey and the staff of the Clinical Microbiology Laboratory, KATH, for providing technical guidance and most of the logistics for this work.

Background and Objective: The antibiogram of the various species of Klebsiella implicated in many infections in Ghana are not known. This study was designed to determine the antibiogram of the various species of Klebsiella isolated from clinical samples in Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana. Materials and Methods: 2197 clinical specimens from the hospital were cultured on blood agar and MacConkey agar and the isolates investigated. The antibiogram of the various Klebsiella species isolated were determined and compared with antibiotics chosen for empirical treatment of 51 paediatric patients in the hospital. Results: Klebsiella species were recovered from 205 clinical samples (9.3% prevalence rate) with K. pneumoniae being the highest recovered species (74.1%), followed by K. oxytoca (24.4%), K. rhinoscleromatis (1%) and K. ozaenae (0.5%). Amikacin was the most potent (80%) against the recovered species whilst cefotaxime, ceftriaxone and gentamicin exhibited approximately 60% potencies. Cefuroxime and ampicillin on the other hand were respectively 75% and 100% resistant. Conclusion: The dominant species of Klebsiella infections were K. pnuemoniae and K. oxytoca. The third generation cephalosporins and aminoglycosides were the potent antibiotics for treatment of Klebsiella infections reported in KATH.

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