AN INSIGHT ON THE ANTIGENIC PREPARATION STRATEGIES INVOLVED IN THE PRODUCTION OF POLYCLONAL ANTIBODIES AGAINST OLIGODENDROGLIOMAS (CEREBRAL TUMORS).

Kapoor R.A.¹, Ladak S.S.², Balaji S. Rao³, Gomase V.S.^4
1Padmashree Dr. D.Y. Patil University, Navi Mumbai, 400614, India
²Padmashree Dr. D.Y. Patil University, Navi Mumbai, 400614, India
³NTHRYS, Hyderabad
⁴School of Technology, S.R.T.M. University, Sub-Centre, Latur, 413512, India

Received : -     Accepted : -     Published : 15-06-2010
Volume : 1     Issue : 1       Pages : 11 - 17
J Clin Res Lett 1.1 (2010):11-17
DOI : http://dx.doi.org/10.9735/0976-7061.1.1.11-17

Conflict of Interest : None declared

Various strategies have been used to identify and characterize the antigens associated with human brain tumors. These approaches have included the raising of polyclonal and antibodies against tumor antigens and, more recently, efforts toward the direct biochemical identification of such proteins. This article summarizes the progress made in this area, suggests reasons for the broad antigenic cross-reactivity and heterogeneity revealed by these studies, and proposes additional methods such as radial and double immunodiffusion and ELISA for deciphering the complex antigenic composition of human brain tumors.

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