ANTI-INFLAMMATORY ACTIVITY OF Cordia dichotoma forst f. SEEDS EXTRACTS

Sharma U.S.¹*, Sharma U.K.², Sutar N.³, Singh A.⁴, Shukla D.K.^5
1Department of Pharmacy, Sir Madanlal Group of Institutions, Etawah-206001, UP, India
²Department of Pharmacy, Sir Madanlal Group of Institutions, Etawah-206001, UP, India
³Department of Pharmacy, Sir Madanlal Group of Institutions, Etawah-206001, UP, India
⁴Department of Pharmacy, Sir Madanlal Group of Institutions, Etawah-206001, UP, India
⁵Shri Guru Ram Rai College of Technology & Science, Dehradun, U.K., India
* Corresponding Author : us_cology@rediffmail.com

Received : -     Accepted : -     Published : 15-06-2010
Volume : 2     Issue : 1       Pages : 1 - 4
Int J Pharmaceut Anal 2.1 (2010):1-4
DOI : http://dx.doi.org/10.9735/0975-3079.2.1.1-4

Keywords : Cordia dichotoma forst, Anti-inflammatory activity, Carrageenan-induced oedema, Dextraninduced oedema, seeds extracts
Conflict of Interest : None declared
Acknowledgements/Funding : The authors are thankful to Mr.Vivek Yadav, Chairmen and Dr.U.K.Sharma, Director, Sir Madanlal Group of Institutions, Etawah (UP) for providing necessary facilities to carryout this research work.

The effects of Cordia dichotoma forst f. seeds extracts on different phases of acute inflammation were examined. Investigations were performed using different phlogistic agents-induced paw edema viz., Carrageenan-induced paw oedema and Dextran- induced paw oedema in rats. Various extracts (ethanol and aqueous) of Cordia dichotoma forst seeds at a dose of 250 mg/kg and 500 mg/kg orally were tested. Diclofenac sodium at the dose of 10mg/kg was used as standard. Both the extracts showed significant activity (*p<0.05 & **p<0.01) compared with the control in both of these models. The dry powdered seeds were found to contain alkaloids, glycosides, saponins, tannins and carbohydrates. Thus it is revealed from the screening model used that the ethanol extract and aqueous fraction of this plant possesses acute antiinflammatory activity.

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