ISSN : 0975-3087
EISSN : 0975-9115
Raja Chakraborty1, Sayak Ganguli2, Hirak Jyoti Chakraborty3, Abhijit Datta4
1Department of Oral Biology, University of Manitoba, Manitoba, Canada R3E0W2
2DBT Centre for Bioinformatics, Presidency College Kolkata, India
3DBT Centre for Bioinformatics, Presidency College Kolkata, India
4DBT Centre for Bioinformatics, Presidency College Kolkata, India
Received : - Accepted : - Published : 21-12-2010
Volume : 2 Issue : 2 Pages : 96 - 102
Int J Bioinformatics Res 2.2 (2010):96-102
DOI : http://dx.doi.org/10.9735/0975-3087.2.2.96-102
Conflict of Interest : None declared
Dopamine has been shown to play a key role in the Central Nervous System. Any imbalance in dopamine production and dopamine receptor activity has been implicated widely in the pharmacology, of a number of neurobehavioral disorders existing today. The dopamine receptors interact with G-proteins to transduce dopamine stimulation into intracellular responses. In this work a 3D structure of DRD5 based on the template of High resolution crystal structure of human ı-2 adrenergic receptor (PDB code 2RH1A) was generated. The model was assessed using MOLPROBITY. The results revealed that 94% of the residues were found in the favoured region of Ramachandran’s plot. Active site analysis showed that predicted binding sites included all the seven transmembrane helices. Our work demonstrates that in silico modeling of proteins has been shown to play an important role in determining protein structure and provides a promising area in possible drug discovery.
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