STRUCTURAL ANALYSIS OF LEUCOCINE – AN ESSENTIAL BACTERIOCIN

Hirak Jyoti Chakraborty¹, Sayak Ganguli²*, Protip Basu³, Paushali Roy⁴, Abhijit Datta^5
1DBT-Centre for Bioinformatics, Presidency College, Kolkata, India.
²DBT-Centre for Bioinformatics, Presidency College, Kolkata, India.
³DBT-Centre for Bioinformatics, Presidency College, Kolkata, India.
⁴DBT-Centre for Bioinformatics, Presidency College, Kolkata, India.
⁵DBT-Centre for Bioinformatics, Presidency College, Kolkata, India.
* Corresponding Author : sayakbif@yahoo.com

Received : -     Accepted : -     Published : 21-12-2010
Volume : 2     Issue : 2       Pages : 1 - 6
Int J Bioinformatics Res 2.2 (2010):1-6
DOI : http://dx.doi.org/10.9735/0975-3087.2.2.1-6

Keywords : Lantibiotics, bacteriocin, homology modelling, Pocket Identification
Conflict of Interest : None declared

Bacterial peptides of low molecular weight displaying antagonism towards other bacterial members are referred to as bacteriocins. Bacteriocins are an essential member of the broadly classified group of lantibiotics which finds several commercial uses. This work comprises of the determination of structure of the most important class of bacteriocins – the leucocin group. Structure elucidation was performed using homology modelling approach and the modeled structure was validated using their Ramachandran calculations. Ligand interaction pockets were identified by calculating the Delaunay triangulation number and structural properties of amino acids were documented. Structure elucidations of such lantibiotics are important for future endeavours towards analyses of protein - protein interactions.

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