AYUR-INFORMATICS: ESTABLISHING AN IN-SILICO-AYURVEDIC MEDICATION FOR ALZHEIMER’S DISEASE

Mohini Gore¹*, Preenon Bagchi², Desai N.S.³, Ajit Kar^4
1Azyme Biosciences Pvt. Ltd., Bangalore-560069
²Padmashree Dr. D.Y. Patil University, Navi Mumbai-400706
³Padmashree Dr. D.Y. Patil University, Navi Mumbai-400706
⁴Satsang Herbal Research Laboratory, S.R. Mandir, Satsang, Deoghar-814116
* Corresponding Author : mohinig@gmail.com

Received : -     Accepted : -     Published : 15-06-2010
Volume : 2     Issue : 1       Pages : 33 - 37
Int J Bioinformatics Res 2.1 (2010):33-37
DOI : http://dx.doi.org/10.9735/0975-3087.2.1.33-37

Keywords : Alzheimer’s disease, Ayurveda, Canscora decussate, Nardostachys jatamansi, Mucuna pruriens, Drug designing
Conflict of Interest : None declared

Alzheimer’s disease is an incurable, degenerative, and terminal disease. It is associated with mutations in Amyloid Precursor Protein (APP), Presenilin 1 (PS1), Presenilin 2 (PS2), or Apolipoprotein E (APOE). 3D structures of these 4 proteins were generated using Homology Modeling. Active compounds of medicinal herbs- Canscora decussate, Nardostachys jatamansi and Mucuna pruriens were selected as these three herbs have properties of memory enhancement. Chemical structures of the active component of these herbs were drawn using chemsketch, combined & converted to *.pdb. The four proteins were successfully docked with Canscora decussate- Nardostachys jatamansi –Mucuna pruriens’s active component combination.

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