ISSN : 0975-3087
EISSN : 0975-9115
Verma D.K.1, Gokhale M.S.2
1Department of Biotechnology and Bioinformatics, Padmashree Dr. D Y Patil University, Navi Mumbai, 400614, India
2Department of Biotechnology and Bioinformatics, Padmashree Dr. D Y Patil University, Navi Mumbai, 400614, India
Received : - Accepted : - Published : 21-12-2009
Volume : 1 Issue : 2 Pages : 65 - 69
Int J Bioinformatics Res 1.2 (2009):65-69
DOI : http://dx.doi.org/10.9735/0975-3087.1.2.65-69
Keywords : Codon Context, Evolution, tRNA, mRNA, Methanocaldococcus jannaschii, amino acids
Conflict of Interest : None declared
Evolution has caused major changes as well as minor changes in the mRNA sequences. Changes in the nucleotides can be result of some selectional pressure leading changes in the codon or due to influences of neighboring codon on selected possible synonymous codon. This research generally analyze the concept of evolutionary constraints on the biased selection of a particular codonpair present in mRNA to be influenced by the 5’-3’ tRNA anti-codon and its neighboring triplet explaining reason for the lesser amount of tRNA in a particular genome as compared to that of the standard genetic code available. The occurrence of one codon next to another has co-evolved with the structure of tRNA and lead to accommodate maximum amount of genetic code to be translated by limited number of tRNA.
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